A
Angelo Parini
Researcher at Paul Sabatier University
Publications - 159
Citations - 6456
Angelo Parini is an academic researcher from Paul Sabatier University. The author has contributed to research in topics: Imidazoline receptor & Monoamine oxidase. The author has an hindex of 42, co-authored 150 publications receiving 5544 citations. Previous affiliations of Angelo Parini include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Rhys Anderson,Anthony B. Lagnado,Damien Maggiorani,Anna Walaszczyk,Emily Dookun,James Chapman,Jodie Birch,Hanna Salmonowicz,Mikolaj Ogrodnik,Diana Jurk,Diana Jurk,Carole J. Proctor,Clara Correia-Melo,Stella Victorelli,Edward Fielder,Rolando Berlinguer-Palmini,A Owens,Laura C. Greaves,Kathy L Kolsky,Angelo Parini,Victorine Douin-Echinard,Nathan K. LeBrasseur,Helen M. Arthur,Simon Tual-Chalot,Marissa J. Schafer,Carolyn M Roos,Jordan D. Miller,Neil Robertson,Jelena Mann,Peter D. Adams,Peter D. Adams,Tamara Tchkonia,James L. Kirkland,Jeanne Mialet-Perez,Gavin D. Richardson,João F. Passos,João F. Passos +36 more
TL;DR: A mechanism by which senescence can occur and contribute to age‐related myocardial dysfunction and in the wider setting to ageing in post‐mitotic tissues is described.
Journal ArticleDOI
Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction.
Céline Mias,Céline Mias,Olivier Lairez,Olivier Lairez,Elodie Trouche,Elodie Trouche,Jerome Roncalli,Denis Calise,Marie-Hélène Seguelas,Catherine Ordener,Marie-Dominique Piercecchi-Marti,Nathalie Augé,Anne Negre Salvayre,Philippe Bourin,Angelo Parini,Angelo Parini,Daniel Cussac,Daniel Cussac +17 more
TL;DR: MSCs modulate the phenotype of cardiac fibroblasts and their ability to degrade extracellular matrix and these properties open new perspectives for understanding the mechanisms of action of MSCs and anticipate their potential therapeutic or side effects.
Journal ArticleDOI
Oxidative Stress by Monoamine Oxidase Mediates Receptor-Independent Cardiomyocyte Apoptosis by Serotonin and Postischemic Myocardial Injury
Pascale Bianchi,Oxana Kunduzova,Emanuela Masini,Claudie Cambon,Daniele Bani,Laura Raimondi,Marie-Hélène Seguelas,Silvia Nistri,Wilson S. Colucci,Nathalie Leducq,Angelo Parini +10 more
TL;DR: The results supply the first direct evidence that oxidative stress induced by MAO is responsible for receptor-independent apoptotic effects of 5-HT in cardiomyocytes and postischemic myocardial injury.
Journal ArticleDOI
CD4+ T Cells Promote the Transition From Hypertrophy to Heart Failure During Chronic Pressure Overload
Fanny Laroumanie,Victorine Douin-Echinard,Joffrey Pozzo,Olivier Lairez,Florence Tortosa,Claire Vinel,Christine Delage,Denis Calise,Marianne Dutaur,Angelo Parini,Nathalie Pizzinat +10 more
TL;DR: A crucial role is demonstrated for the first time a crucial role of CD4+ T cells and specific antigen recognition in the progression from compensated cardiac hypertrophy to HF.
Journal ArticleDOI
Ex Vivo Pretreatment with Melatonin Improves Survival, Proangiogenic/Mitogenic Activity, and Efficiency of Mesenchymal Stem Cells Injected into Ischemic Kidney
Céline Mias,Elodie Trouche,Marie-Hélène Seguelas,Fabien Calcagno,Françoise Dignat-George,Florence Sabatier,Marie-Dominique Piercecchi-Marti,Laurent Daniel,Pascale Bianchi,Denis Calise,Philippe Bourin,Angelo Parini,Angelo Parini,Daniel Cussac,Daniel Cussac +14 more
TL;DR: A strategy of ex vivo pretreatment with the pineal hormone melatonin to improve survival, paracrine activity, and efficiency of bone marrow mesenchymal stem cells is designed.