M
Marieke Simonis
Researcher at Utrecht University
Publications - 23
Citations - 3151
Marieke Simonis is an academic researcher from Utrecht University. The author has contributed to research in topics: Chromosome conformation capture & Gene. The author has an hindex of 17, co-authored 23 publications receiving 2896 citations. Previous affiliations of Marieke Simonis include Royal Netherlands Academy of Arts and Sciences & Erasmus University Rotterdam.
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Journal ArticleDOI
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)
Marieke Simonis,Petra Klous,Erik Splinter,Yuri M. Moshkin,Rob Willemsen,Elzo de Wit,Bas van Steensel,Wouter de Laat +7 more
TL;DR: It is demonstrated here that active and inactive genes are engaged in many long-range intrachromosomal interactions and can also form interchromosomal contacts and establish 4C technology as a powerful tool to study nuclear architecture.
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Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes
Sebastiaan van Heesch,Maarten van Iterson,Jetse Jacobi,Sander Boymans,Paul B. Essers,Ewart de Bruijn,Wensi Hao,Alyson W. MacInnes,Edwin Cuppen,Marieke Simonis +9 more
TL;DR: The findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes.
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An evaluation of 3C-based methods to capture DNA interactions.
TL;DR: The intricacies of 3C and new 3C-based methods including the 4C, 5C and ChIP-loop assay are discussed, for example, to demonstrate that regulatory DNA elements communicate with distant target genes through direct physical interactions that loop out the intervening chromatin fiber.
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Interactions among Polycomb Domains Are Guided by Chromosome Architecture
Bas Tolhuis,Marleen Blom,Ron M. Kerkhoven,Ludo Pagie,Hans Teunissen,Marja Nieuwland,Marieke Simonis,Wouter de Laat,Maarten van Lohuizen,Bas van Steensel +9 more
TL;DR: This work adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal interactions in Drosophila melanogaster larval brain tissue and demonstrates that many interactions among PcG target genes exist and that these interactions are guided by overall chromosome architecture.
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Variegated gene expression caused by cell-specific long-range DNA interactions
Daan Noordermeer,Elzo de Wit,Petra Klous,Harmen J.G. van de Werken,Marieke Simonis,Melissa Lopez-Jones,Bert Eussen,Annelies de Klein,Robert H. Singer,Wouter de Laat +9 more
TL;DR: Mammalian genomes contain numerous regulatory DNA sites with unknown target genes, and cell-specific long-range DNA contacts can cause variegated expression, demonstrating genetically that mammalian trans activation is possible, but suggests that it will be rare.