M
Marija Cemma
Researcher at University of Toronto
Publications - 8
Citations - 543
Marija Cemma is an academic researcher from University of Toronto. The author has contributed to research in topics: Phagosome & Autophagy. The author has an hindex of 6, co-authored 8 publications receiving 467 citations. Previous affiliations of Marija Cemma include Hospital for Sick Children.
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Journal ArticleDOI
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway
TL;DR: It is concluded that p62 and NDP52 act cooperatively to drive efficient antibacterial autophagy by targeting the protein complexes they coordinate to distinct microdomains associated with bacteria.
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Interactions of Pathogenic Bacteria with Autophagy Systems
Marija Cemma,John H. Brumell +1 more
TL;DR: This minireview highlights the complicated relationship between autophagy components and intracellular bacteria, including bacterial targeting mechanisms and the interaction between Autophagy and effectors/toxins secreted by bacteria.
Journal ArticleDOI
Host and bacterial factors that regulate LC3 recruitment to Listeria monocytogenes during the early stages of macrophage infection
TL;DR: The data suggest that the LC3-associated phagocytosis (LAP) pathway, which is distinct from macroautophagy, targets L. monocytogenes during the early stage of infection within host macrophages and allows establishment of an intracellular niche (SLAPs) associated with persistent infection.
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An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread.
Joel M J Tan,Nora Mellouk,Suzanne E. Osborne,Dustin A. Ammendolia,Diana N Dyer,Ren Li,Diede Brunen,Jorik M. van Rijn,Ju Huang,Mark A. Czuczman,Marija Cemma,Amy Won,Christopher M. Yip,Ramnik J. Xavier,Donna A. MacDuff,Fulvio Reggiori,Fulvio Reggiori,Jayanta Debnath,Tamotsu Yoshimori,Peter K. Kim,Gregory D. Fairn,Gregory D. Fairn,Etienne Coyaud,Brian Raught,Brian Raught,Aleixo M. Muise,Darren E. Higgins,John H. Brumell +27 more
TL;DR: It is shown that autophagy-related protein ATG16L1 and its binding partners ATG5 and ATG12 are required for plasma membrane repair through a pathway independent of macroautophagy, and help to restrict Listeria monocytogenes toxin-mediated cell-to-cell spread.
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Autophagy proteins are not universally required for phagosome maturation.
TL;DR: It is proposed that ATG proteins may be required for phagosome maturation under some conditions, but are not universally required for this process.