C
Christopher M. Yip
Researcher at University of Toronto
Publications - 158
Citations - 8398
Christopher M. Yip is an academic researcher from University of Toronto. The author has contributed to research in topics: Membrane & Lipid bilayer. The author has an hindex of 46, co-authored 138 publications receiving 7667 citations. Previous affiliations of Christopher M. Yip include Paris Descartes University & University of Alberta.
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Journal ArticleDOI
α-Synuclein Membrane Interactions and Lipid Specificity
Euijung Jo,JoAnne McLaurin,Christopher M. Yip,Peter St George-Hyslop,Peter St George-Hyslop,Paul E. Fraser +5 more
TL;DR: The results suggest that α-Syn membrane interactions are physiologically important and the lipid composition of the cellular membranes may affect these interactions in vivo.
Journal ArticleDOI
Roles of Hydrophobicity and Charge Distribution of Cationic Antimicrobial Peptides in Peptide-Membrane Interactions
TL;DR: The overall findings suggest optimum routes to balancing peptide hydrophobicity and charge distribution that allow efficient penetration and disruption of the bacterial membranes without damage to mammalian (host) membranes.
Journal ArticleDOI
Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation
Nicolas Touret,Paul Paroutis,Mauricio R. Terebiznik,Rene E. Harrison,Sergio Trombetta,Marc Pypaert,Amy Y. M. Chow,Aimin Jiang,James E. Shaw,Christopher M. Yip,Hsiao-Ping H. Moore,Nicole N. van der Wel,Diane Houben,Peter J. Peters,Chantal de Chastellier,Ira Mellman,Sergio Grinstein +16 more
TL;DR: The data indicate that the plasma membrane is the main constituent of nascent and newly formed phagosomes, which are progressively remodeled by fusion with endosomal and eventually lysosomal compartments as phagosome mature into acidic, degradative organelles.
Journal ArticleDOI
Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.
Mauricio R. Terebiznik,Otilia V. Vieira,Sandra L. Marcus,Andrea Slade,Christopher M. Yip,William S. Trimble,Tobias Meyer,B. Brett Finlay,Sergio Grinstein +8 more
TL;DR: It is shown that the outermost parts of the ruffles induced by invasion show a modest enrichment in PtdIns(4,5)P2, but that Ptd insurance is virtually absent from the invaginating regions.
Matters Arising Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation
Nicolas Touret,Paul Paroutis,Mauricio R. Terebiznik,Rene E. Harrison,Sergio Trombetta,Marc Pypaert,Amy Y. M. Chow,Aimin Jiang,James E. Shaw,Christopher M. Yip,Hsiao-Ping H. Moore,Nicole N. van der Wel,Diane Houben,Peter J. Peters,Chantal de Chastellier,Ira Mellman,Sergio Grinstein +16 more
TL;DR: Gagnon et al. as discussed by the authors used a combination of biochemical,fluorescence imaging, and electron microscopy tech-niques to quantitatively and dynamically assess the contribution of the plasmalemma and of the endoplasmic reticu-lum (ER) to phagosome formation and maturation.