M
Marine Adlanmerini
Researcher at French Institute of Health and Medical Research
Publications - 21
Citations - 908
Marine Adlanmerini is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Estrogen receptor & Estrogen. The author has an hindex of 9, co-authored 18 publications receiving 657 citations. Previous affiliations of Marine Adlanmerini include Paul Sabatier University & University of Toulouse.
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Journal ArticleDOI
Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
Jean-François Arnal,Françoise Lenfant,Raphaël Métivier,Gilles Flouriot,Daniel Henrion,Marine Adlanmerini,Coralie Fontaine,Pierre Gourdy,Pierre Chambon,Benita S. Katzenellenbogen,John A. Katzenellenbogen,John A. Katzenellenbogen,John A. Katzenellenbogen +12 more
TL;DR: The in vitro studies that are the basis of the current understanding of the mechanisms of action of ERα as a nuclear receptor and the key roles played by its two activation functions (AFs) in its transcriptional activities are summarized.
Journal ArticleDOI
Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions
Marine Adlanmerini,Romain Solinhac,Anne Abot,Aurelie Fabre,Isabelle Raymond-Letron,Anne-Laure Guihot,Frédéric Boudou,Lucile Sautier,Lucile Sautier,Emilie Vessieres,Sung Hoon Kim,Philippe Liere,Coralie Fontaine,Andrée Krust,Pierre Chambon,John A. Katzenellenbogen,Pierre Gourdy,Philip W. Shaul,Daniel Henrion,Jean-François Arnal,Françoise Lenfant +20 more
TL;DR: Genetically segregated membrane versus nuclear actions of a steroid hormone receptor and demonstrated their in vivo tissue-specific roles for the first time.
Journal ArticleDOI
Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis
Christel Pequeux,Isabelle Raymond-Letron,Silvia Blacher,Frédéric Boudou,Marine Adlanmerini,Marie-José Fouque,Philippe Rochaix,Agnès Noël,Jean-Michel Foidart,Andrée Krust,Pierre Chambon,Laurent Brouchet,Jean-François Arnal,Françoise Lenfant +13 more
TL;DR: It is shown that E2 promotes the growth of ERα-negative cancer cells through the activation of stromal ERα (extra-hematopoietic Tie-2 positive cells), which normalizes tumor angiogenesis and allows an adaptation of blood supply to tumors, thereby preventing hypoxia and necrosis.
Journal ArticleDOI
The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation
Anne Abot,Coralie Fontaine,Melissa Buscato,Romain Solinhac,Gilles Flouriot,Aurelie Fabre,Anne Drougard,Shyamala S. Rajan,Muriel Laine,Alain Milon,Isabelle Muller,Daniel Henrion,Marine Adlanmerini,Marie Cécile Valera,Anne Gompel,Céline Gérard,Christel Pequeux,Mélanie Mestdagt,Isabelle Raymond-Letron,Claude Knauf,François Ferrière,Philippe Valet,Pierre Gourdy,Benita S. Katzenellenbogen,John A. Katzenellenbogen,Françoise Lenfant,Geoffrey L. Greene,Jean-Michel Foidart,Jean-François Arnal +28 more
TL;DR: This profile of ERα activation by E4, uncoupling nuclear and membrane activation, characterizes E4 as a selective ER modulator which could have medical applications that should now be considered further.
Journal ArticleDOI
The AF-1 Activation Function of Estrogen Receptor α Is Necessary and Sufficient for Uterine Epithelial Cell Proliferation In Vivo
Anne Abot,Coralie Fontaine,Isabelle Raymond-Letron,Gilles Flouriot,Marine Adlanmerini,Melissa Buscato,Christiane Otto,Hortense Berges,Henrik Laurell,Pierre Gourdy,Françoise Lenfant,Jean-François Arnal +11 more
TL;DR: It is shown that acute treatment with E2 or tamoxifen, which selectively activates ERαAF-1, similarly regulate the expression of a uterine set of estrogen-dependent genes as well as epithelial cell proliferation in the uterus of wild-type mice.