Mario C. Deng

TL;DR: Gene expression testing can detect absence of moderate/severe rejection, thus avoiding biopsy in certain clinical settings, and the role of molecular testing for clinical event prediction and immunosuppression management is established.

TL;DR: Among selected patients who had received a cardiac transplant more than 6 months previously and who were at a low risk for rejection, a strategy of monitoring for rejection that involved gene-expression profiling, as compared with routine biopsy was not associated with an increased risk of serious adverse outcomes and resulted in the performance of significantly fewer biopsies.

TL;DR: Heart transplantation using donor hearts adequately preserved with the Organ Care System or with standard cold storage yield similar short-term clinical outcomes and the metabolic assessment capability of the Organ care System needs further study.

TL;DR: The Scientific Council on Mechanical Circulatory Support of the International Society for Heart and Lung Transplantation has established an international database to generate critical data to advance knowledge about the effectiveness of mechanical circulatory support device therapy for one of the most difficult and costly contemporary medical problems, the malignant syndrome of advanced heart failure.