G
Giorgio Fanò
Researcher at University of Perugia
Publications - 69
Citations - 3902
Giorgio Fanò is an academic researcher from University of Perugia. The author has contributed to research in topics: Skeletal muscle & Myocyte. The author has an hindex of 30, co-authored 68 publications receiving 3688 citations. Previous affiliations of Giorgio Fanò include University of Chieti-Pescara.
Papers
More filters
Journal ArticleDOI
Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.
Gabriella Dobrowolny,Michela Aucello,Emanuele Rizzuto,Sara Beccafico,Cristina Mammucari,Simona Bonconpagni,Silvia Belia,Francesca Wannenes,Carmine Nicoletti,Zaccaria Del Prete,Nadia Rosenthal,Mario Molinaro,Feliciano Protasi,Giorgio Fanò,Marco Sandri,Antonio Musarò,Antonio Musarò +16 more
TL;DR: It is demonstrated that skeletal muscle is a primary target of SOD1(G93A) -mediated toxicity and the molecular mechanism whereby oxidative stress triggers muscle atrophy is disclosed.
Journal ArticleDOI
Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle
Patrizia Mecocci,Giorgio Fanò,Stefania Fulle,Usha MacGarvey,Leslie A. Shinobu,M. Cristina Polidori,Antonio Cherubini,Jacopo Vecchiet,Umberto Senin,M. Flint Beal +9 more
TL;DR: Age-dependent increases in 8-hydroxy-2-deoxyguanosine (OH8dG) and malondialdehyde (MDA) provided evidence for a role of oxidative damage in human aging which may contribute to age-dependent losses of muscle strength and stamina.
Journal ArticleDOI
The contribution of reactive oxygen species to sarcopenia and muscle ageing
Stefania Fulle,Feliciano Protasi,Guglielmo Di Tano,Tiziana Pietrangelo,Andrea Beltramin,Simona Boncompagni,Leonardo Vecchiet,Giorgio Fanò +7 more
TL;DR: A significant reduction of the regenerative potential of muscle fibres is due to a reduced pool of satellite cells that are usually recruited to replace damaged fibres and promote their regeneration.
Journal ArticleDOI
The S-100: a protein family in search of a function.
TL;DR: "In vitro" and "in vivo" experiments showed that lower (nM) concentrations of extracellular S-100 beta act on glial and neuronal cells as a growth-differentiating factor and higher concentrations of the protein induce apoptosis of some cells such as the sympathetic-like PC12 line.
Journal ArticleDOI
Long-term denervation in humans causes degeneration of both contractile and excitation-contraction coupling apparatus, which is reversible by functional electrical stimulation (FES): a role for myofiber regeneration?
Helmut Kern,Simona Boncompagni,Katia Rossini,Winfried Mayr,Giorgio Fanò,Maria Elena Zanin,Marzena Podhorska-Okolow,Marzena Podhorska-Okolow,Feliciano Protasi,Ugo Carraro +9 more
TL;DR: It is demonstrated that the protocol used during FES training is effective in reverting long-term denervation atrophy and dystrophy and the structural results of muscle trained using FES are presented.