Emanuele Rizzuto

TL;DR: It is demonstrated that skeletal muscle is a primary target of SOD1(G93A) -mediated toxicity and the molecular mechanism whereby oxidative stress triggers muscle atrophy is disclosed.

TL;DR: It is shown that local expression of a muscle‐restricted insulin‐like growth factor (IGF)‐1 (mIGF‐1) transgene accelerates the regenerative process of injured skeletal muscle, modulating the inflammatory response, and limiting fibrosis.

TL;DR: The C26 tumor, ectopically implanted in mice, is an undifferentiated carcinoma, which should be referred to as such and not as adenocarcinoma, a common misconception, and represents a well standardized experimental model for research on cancer cachexia.

TL;DR: It is found that the autophagic flux is overloaded in skeletal muscle of both colon carcinoma murine models and patients, but not in running C26-bearing mice, thus suggesting that exercise may release the autophile flux and ultimately rescue muscle homeostasis.

TL;DR: It is reported that only IGF‐1Ea expression promotes a pronounced hypertrophic phenotype in young mice, which is maintained in aged mice, and data suggest that IGF‐ 1 is a promising therapeutic agent in staving off advancing muscle weakness.