Francesca Wannenes

TL;DR: It is demonstrated that skeletal muscle is a primary target of SOD1(G93A) -mediated toxicity and the molecular mechanism whereby oxidative stress triggers muscle atrophy is disclosed.

TL;DR: It is shown that local expression of a muscle‐restricted insulin‐like growth factor (IGF)‐1 (mIGF‐1) transgene accelerates the regenerative process of injured skeletal muscle, modulating the inflammatory response, and limiting fibrosis.

TL;DR: It is shown for the first time that the Akt activity might be a relevant molecular event linking the NHE-1-regulated intracellular pH and the Wnt/β-catenin signaling in tumor cells, providing evidence for a cross-talk between the intrACEllular alkalinization and theWnt signaling in tumors cells.

TL;DR: Testosterone induces myogenin, myosin heavy chains (MyHC) and GRIP-1 expression, suggesting that AR and its coregulatory proteins are pivotal factors in skeletal muscle differentiation.

TL;DR: Investigation of spontaneous and H(2)O(2)-induced oxidative stress and apoptosis levels in peripheral blood mononuclear cells from MCI and AD patients, as well as from Parkinson's disease patients without cognitive impairment or age-matched healthy control indicates changes as potential biomarkers in the early diagnosis of AD.