M
Marion M. Maetens
Researcher at University of Toronto
Publications - 6
Citations - 919
Marion M. Maetens is an academic researcher from University of Toronto. The author has contributed to research in topics: Transgene & Mdm2. The author has an hindex of 6, co-authored 6 publications receiving 868 citations. Previous affiliations of Marion M. Maetens include Flanders Institute for Biotechnology & Free University of Brussels.
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Journal ArticleDOI
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4.
Jean-Christophe Marine,Sarah Francoz,Marion M. Maetens,Geoffrey M. Wahl,Franck Toledo,Franck Toledo,Guillermina Lozano +6 more
TL;DR: This work presents a novel and scalable approach to gene expression engineering that allows for real-time annotation of gene expression changes in response to cancerigenicity and shows promise in finding novel and efficient treatments for cancer.
Journal ArticleDOI
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
Sarah Francoz,Pascal Froment,Sven Bogaerts,Sarah De Clercq,Marion M. Maetens,Gilles Doumont,Eric Bellefroid,Jean-Christophe Marine +7 more
TL;DR: A p53 knock-in allele is combined, in which p53 is silenced by a transcriptional stop element flanked by loxP sites, with the mdm2- and mdm4-null alleles, which allows Cre-mediated conditional p53 expression in tissues in vivo and cells in vitro lacking Mdm2, Mdm4, or both.
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Evolutionarily Conserved Role of Nucleostemin: Controlling Proliferation of Stem/Progenitor Cells during Early Vertebrate Development
Chantal Beekman,Massimo Nichane,Sarah De Clercq,Marion M. Maetens,Thomas Floss,Wolfgang Wurst,Eric Bellefroid,Jean-Christophe Marine +7 more
TL;DR: The results show that NS has a unique ability, derived from an ancestral function, to control the proliferation rate of stem/progenitor cells in vivo independently of p53.
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Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells
Omar Nyabi,Michael Naessens,Katharina Haigh,Agnieszka Gembarska,Steven Goossens,Marion M. Maetens,Sarah De Clercq,Benjamin Drogat,Lieven Haenebalcke,Sonia Bartunkova,Ilse De Vos,Bram De Craene,Mansour Karimi,Geert Berx,András D Nagy,Pierre Hilson,Jean-Christophe Marine,Jody J. Haigh +17 more
TL;DR: The ability to rapidly and efficiently generate reliable Cre/loxP conditional transgenic mice would greatly complement global high-throughput gene targeting initiatives aimed at identifying gene function in the mouse by using Gateway® cloning to build the target vectors.
Journal ArticleDOI
Distinct roles of Mdm2 and Mdm4 in red cell production
Marion M. Maetens,Marion M. Maetens,Gilles Doumont,Sarah De Clercq,Sarah Francoz,Sarah Francoz,Pascal Froment,Eric Bellefroid,Ursula Klingmüller,Guillermina Lozano,Jean-Christophe Marine +10 more
TL;DR: The data show that Mdm2 is required for rescuing erythroid progenitors from p53-mediated apoptosis during primitive erythropoiesis, and Mdm4 only contributes to p53 regulation at a specific phase of the differentiation program.