M
Mark M. Kockx
Researcher at University of Antwerp
Publications - 159
Citations - 12365
Mark M. Kockx is an academic researcher from University of Antwerp. The author has contributed to research in topics: Apoptosis & Macrophage. The author has an hindex of 55, co-authored 153 publications receiving 11076 citations.
Papers
More filters
Journal ArticleDOI
Development and Validation of a Histological Method to Measure Microvessel Density in Whole-Slide Images of Cancer Tissue
Koen M. Marien,Valerie Croons,Yannick Waumans,Ellen Sluydts,Stefanie De Schepper,Luc Andries,Wim Waelput,Erik Fransen,Peter B. Vermeulen,Mark M. Kockx,Guido R.Y. De Meyer +10 more
TL;DR: An improved microvessel density quantification method in tumor tissue based on stereological principles and using whole-slide images is presented and inter-observer concordance improved considerably.
Journal ArticleDOI
In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity
Rob Krams,Stefan Verheye,Luc C.A. van Damme,Dennie Tempel,Babak Mousavi Gourabi,Eric Boersma,Mark M. Kockx,Michiel W.M. Knaapen,Chaylendra Strijder,Glenn Van Langenhove,Gerard Pasterkamp,Anton F. W. van der Steen,Patrick W. Serruys +12 more
TL;DR: In vivo temperature measurements enable to detect plaques that contain more macrophages, less SMCs, and a higher MMP-9 activity, better than macrophage accumulation alone.
Journal ArticleDOI
Gene Expression Profiling in BRAF-Mutated Melanoma Reveals Patient Subgroups with Poor Outcomes to Vemurafenib That May Be Overcome by Cobimetinib Plus Vemurafenib
Matthew Wongchenko,Grant A. McArthur,Brigitte Dréno,James Larkin,Paolo A. Ascierto,Jeffrey A. Sosman,Luc Andries,Mark M. Kockx,Stephen D. Hurst,Ivor Caro,Isabelle Rooney,Priti S. Hegde,Luciana Molinero,Huibin Yue,Ilsung Chang,Lukas C. Amler,Yibing Yan,Antoni Ribas +17 more
TL;DR: In vemurafenib-treated patients, the cell-cycle gene signature was associated with shorter PFS, however, in cobimetinib combined with vemurAFenib treated patients, both cell cycle and immune signature subgroups had comparable PFS.
Journal ArticleDOI
Overexpression of the anti-apoptotic caspase-2 short isoform in macrophage-derived foam cells of human atherosclerotic plaques.
TL;DR: Strong caspase-2 immunoreactivity is reported in foam cells of macrophage-origin around the necrotic core of advanced human atherosclerotic plaques that might be up-regulated in response to DNA damage.
Journal ArticleDOI
Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability during cholesterol lowering in rabbits.
Guido R.Y. De Meyer,Mark M. Kockx,Michiel W.M. Knaapen,Wim Martinet,Dieter M. M. De Cleen,Hidde Bult,Arnold G. Herman +6 more
TL;DR: It is demonstrated that molsidomine, when combined with cholesterol lowering, decreases signs of oxidative stress and increases features of stable atherosclerotic plaques.