Mark M. Kockx

TL;DR: Although both smooth muscle cells and macrophages within the human fatty streaks become susceptible to apoptosis, additional factors are necessary to terminate the cell death pathway, and the TUNEL technique should be combined with additional techniques, such as markers of transcription and morphological criteria.

TL;DR: It is thought that the TUNEL technique should be combined with additional techniques, such as markers of transcription and morphological criteria, as these contain a far greater degree of DNA fragmentation than non-apoptotic nuclei.

TL;DR: Observations strongly suggest that caspase-14 is involved in the keratinocyte terminal differentiation program leading to normal skin cornification, while the executioner caspases are not implicated.

TL;DR: Focal intraplaque microhemorrhages initiate platelet and erythrocyte phagocytosis, leading to iron deposition, macrophage activation, ceroid production, and foam cell formation, and neovascularization can thus promote focal plaque expansion when microvessels become thrombotic or rupture prone.

TL;DR: A strategy to promote (thrombotic) rupture of preexisting atherosclerotic lesions using p53-induced lesion remodeling is described to delineate the processes that precede rupture and to evaluate plaque-stabilizing therapies.