M
Mark Matzas
Researcher at Torrey Pines Institute for Molecular Studies
Publications - 12
Citations - 699
Mark Matzas is an academic researcher from Torrey Pines Institute for Molecular Studies. The author has contributed to research in topics: Nucleic acid & DNA sequencing. The author has an hindex of 7, co-authored 12 publications receiving 666 citations. Previous affiliations of Mark Matzas include University of Hamburg.
Papers
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Journal ArticleDOI
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing
Andreas Keller,Angela Graefen,Markus Ball,Mark Matzas,Valesca Boisguerin,Frank Maixner,Petra Leidinger,Christina Backes,Rabab Khairat,Michael Forster,Bjoern Stade,Andre Franke,Jens Mayer,Jessica Spangler,Stephen F. McLaughlin,Minita Shah,Clarence Lee,Timothy T. Harkins,Alexander Sartori,Andrés Moreno-Estrada,Brenna M. Henn,Martin Sikora,Ornella Semino,Jacques Chiaroni,Siiri Rootsi,Natalie M. Myres,Vicente M. Cabrera,Peter A. Underhill,Carlos Bustamante,Eduard Egarter Vigl,Marco Samadelli,Giovanna Cipollini,Jan Haas,Hugo A. Katus,Brian O'Connor,Marc R. J. Carlson,Benjamin Meder,Nikolaus Blin,Nikolaus Blin,Eckart Meese,Carsten M. Pusch,Albert Zink +41 more
TL;DR: The complete genome sequence of the Iceman is reported and 100% concordance between the previously reported mitochondrial genome sequence and the consensus sequence generated from the genomic data is shown.
Journal ArticleDOI
High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing
Mark Matzas,Peer F. Stähler,Nathalie Kefer,Nicole Siebelt,Valesca Boisguerin,Jack T. Leonard,Andreas Keller,Cord F. Stähler,Pamela Häberle,Baback Gharizadeh,Farbod Babrzadeh,George M. Church,George M. Church +12 more
TL;DR: This work describes a highly parallel and miniaturized method for obtaining high-quality DNA by using next-generation sequencing (NGS) technology as a preparative tool and uses DNA obtained by megacloning to assemble synthetic genes.
Journal ArticleDOI
Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients
Andreas Keller,Andreas Keller,Christina Backes,Petra Leidinger,Nathalie Kefer,Valesca Boisguerin,Catalin Barbacioru,Britta Vogel,Mark Matzas,Hanno Huwer,Hugo A. Katus,Cord F. Stähler,Benjamin Meder,Eckart Meese +13 more
TL;DR: It is demonstrated that deep sequencing of small RNAs bears high potential to quantify miRNAAs in peripheral blood and to identify previously unknown miRNAs serving as biomarker for lung cancer, and developed a bioinformatics pipeline to generate profiles of miRNA markers and to detect novel mi RNAs with diagnostic information.
Patent
Synthesis of sequence-verified nucleic acids
Peer F. Stähler,Raphaël Carapito,Cord F. Stähler,Mark Matzas,Jack T. Leonard,Joachim Jäger,Markus Beier +6 more
Journal ArticleDOI
Identification of Novel SNPs in Glioblastoma Using Targeted Resequencing
Andreas Keller,Christian Harz,Mark Matzas,Benjamin Meder,Hugo A. Katus,Nicole Ludwig,Ulrike Fischer,Eckart Meese +7 more
TL;DR: To detect novel single nucleotide polymorphisms (SNPs) for glioblastoma multiforme (GBM), a combination of specific target selection and next generation sequencing (NGS) was used and several of the detected SNPs were previously associated with smoking behavior, body mass index, breast cancer and high-grade glioma.