B
Bjoern Stade
Researcher at University of Kiel
Publications - 6
Citations - 621
Bjoern Stade is an academic researcher from University of Kiel. The author has contributed to research in topics: Iceman & Proteome. The author has an hindex of 5, co-authored 6 publications receiving 575 citations.
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Journal ArticleDOI
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing
Andreas Keller,Angela Graefen,Markus Ball,Mark Matzas,Valesca Boisguerin,Frank Maixner,Petra Leidinger,Christina Backes,Rabab Khairat,Michael Forster,Bjoern Stade,Andre Franke,Jens Mayer,Jessica Spangler,Stephen F. McLaughlin,Minita Shah,Clarence Lee,Timothy T. Harkins,Alexander Sartori,Andrés Moreno-Estrada,Brenna M. Henn,Martin Sikora,Ornella Semino,Jacques Chiaroni,Siiri Rootsi,Natalie M. Myres,Vicente M. Cabrera,Peter A. Underhill,Carlos Bustamante,Eduard Egarter Vigl,Marco Samadelli,Giovanna Cipollini,Jan Haas,Hugo A. Katus,Brian O'Connor,Marc R. J. Carlson,Benjamin Meder,Nikolaus Blin,Nikolaus Blin,Eckart Meese,Carsten M. Pusch,Albert Zink +41 more
TL;DR: The complete genome sequence of the Iceman is reported and 100% concordance between the previously reported mitochondrial genome sequence and the consensus sequence generated from the genomic data is shown.
Journal ArticleDOI
Early-onset Crohn’s disease and autoimmunity associated with a variant in CTLA-4
Sebastian Zeissig,Britt-Sabina Petersen,Michal Tomczak,Espen Melum,Emilie Huc-Claustre,Stephanie K. Dougan,Jon K. Laerdahl,Bjoern Stade,Michael Forster,Stefan Schreiber,Dascha C. Weir,Alan M. Leichtner,Andre Franke,Richard S. Blumberg +13 more
TL;DR: The results support the concept that variants in CTLA4 provide the basis for a novel Mendelian form of early-onset CD associated with systemic autoimmunity and indicate the presence of other genetic and/or environmental modifiers.
Journal ArticleDOI
Whole genome and exome sequencing of monozygotic twins discordant for Crohn’s disease
Britt-Sabina Petersen,Martina E. Spehlmann,Andreas Raedler,Bjoern Stade,Ingo Thomsen,Raquel Rabionet,Philip Rosenstiel,Stefan Schreiber,Andre Franke +8 more
TL;DR: This study constitutes the first to perform whole genome sequencing for CD twins and therefore provides a valuable reference dataset for future studies and presents an example framework for mosaicism detection and point to the challenges in these types of analyses.
Journal ArticleDOI
Paleoproteomic study of the Iceman's brain tissue.
Frank Maixner,Thorsten Overath,Dennis Linke,Marek Janko,Gea Guerriero,Bart H. J. van den Berg,Bjoern Stade,Petra Leidinger,Christina Backes,Marta Jaremek,Benny Kneissl,Benjamin Meder,Andre Franke,Eduard Egarter-Vigl,Eckart Meese,Andreas Schwarz,Andreas Tholey,Albert Zink,Andreas Keller,Andreas Keller +19 more
TL;DR: The proteome of two distinct brain samples is studied using gel-based and liquid chromatography–mass spectrometry-based proteomics technologies together with a multiple-databases and -search algorithms-driven data-analysis approach, finding 41 proteins known to be highly abundant in brain tissue and 9 specifically expressed in the brain.
Journal ArticleDOI
GrabBlur - a framework to facilitate the secure exchange of whole-exome and -genome SNV data using VCF files
TL;DR: GrabBlur is a newly developed tool to aggregate and share NGS-derived single nucleotide variant (SNV) data in a public database, keeping individual samples unidentifiable, so that it is impossible to reconstruct complete exomes or genomes from the database or to re-identify single individuals.