A
Annick Itie
Researcher at Ontario Institute for Cancer Research
Publications - 18
Citations - 11206
Annick Itie is an academic researcher from Ontario Institute for Cancer Research. The author has contributed to research in topics: Gene targeting & Kinase. The author has an hindex of 18, co-authored 18 publications receiving 10760 citations. Previous affiliations of Annick Itie include University of Toronto & University Health Network.
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Journal ArticleDOI
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
Journal ArticleDOI
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
Mark A. Lomaga,Wen Chen Yeh,Ildiko Sarosi,Gordon S. Duncan,Caren Furlonger,Alexandra Ho,Sean Morony,Casey Capparelli,Gwyneth Van,Stephen Kaufman,Annette Van Der Heiden,Annick Itie,Andrew Wakeham,Wilson Khoo,Takehiko Sasaki,Zhaodan Cao,Josef M. Penninger,Christopher J. Paige,David L. Lacey,Colin R. Dunstan,William J. Boyle,David V. Goeddel,Tak W. Mak +22 more
TL;DR: It is reported that mice deficient in TNF receptor-associated factor 6 (TRAF6) are osteopetrotic with defects in bone remodeling and tooth eruption due to impaired osteoclast function, and it is demonstrated that TRAF6 is crucial not only in IL-1 and CD40 signaling but also, surprisingly, in LPS signaling.
Journal ArticleDOI
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
Takehiko Sasaki,Junko Irie-Sasaki,Junko Irie-Sasaki,Russell G. Jones,Antonio J. Oliveira-dos-Santos,William L. Stanford,Brad Bolon,Andrew Wakeham,Annick Itie,Dennis Bouchard,Ivona Kozieradzki,Nicholas Joza,Tak W. Mak,Tak W. Mak,Pamela S. Ohashi,Akira Suzuki,Akira Suzuki,Josef M. Penninger,Josef M. Penninger +18 more
TL;DR: It is shown that PI3Kgamma controls thymocyte survival and activation of mature T cells but has no role in the development or function of B cells.
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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nobutaka Suzuki,Shinobu Suzuki,Gordon S. Duncan,Douglas G. Millar,Teiji Wada,Christine Mirtsos,Hidetoshi Takada,Andrew Wakeham,Annick Itie,Shyun Li,Josef M. Penninger,Holger Wesche,Pamela S. Ohashi,Tak W. Mak,Wen Chen Yeh +14 more
TL;DR: It is shown by gene-targeting that IRAK-4, an IRAK molecule closely related to the Drosophila Pelle protein, is indispensable for the responses of animals and cultured cells to IL-1 and ligands that stimulate various TLRs.
Journal ArticleDOI
ICOS is essential for effective T-helper-cell responses.
Anna Tafuri,Arda Shahinian,Arda Shahinian,Friedhelm Bladt,Steve K. Yoshinaga,Manel Jordana,Andrew Wakeham,Andrew Wakeham,Louis-Martin Boucher,Louis-Martin Boucher,Denis Bouchard,Denis Bouchard,Vera S. F. Chan,Gordon S. Duncan,Gordon S. Duncan,Bernhard Odermatt,Alexandra Ho,Alexandra Ho,Annick Itie,Annick Itie,Tom Horan,John Whoriskey,Tony Pawson,Josef M. Penninger,Josef M. Penninger,Pamela S. Ohashi,Tak W. Mak,Tak W. Mak +27 more
TL;DR: In vivo genetic evidence is provided that ICOS delivers a co-stimulatory signal that is essential both for efficient interaction between T and B cells and for normal antibody responses to T-cell-dependent antigens.