R
Richard A. G. Smith
Researcher at King's College London
Publications - 108
Citations - 4185
Richard A. G. Smith is an academic researcher from King's College London. The author has contributed to research in topics: Transplantation & Complement system. The author has an hindex of 33, co-authored 106 publications receiving 3809 citations. Previous affiliations of Richard A. G. Smith include University of Sheffield & Guy's and St Thomas' NHS Foundation Trust.
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Journal ArticleDOI
Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS.
Kathrin Meyer,Laura Ferraiuolo,Carlos Henrique Miranda,Shibi Likhite,Shibi Likhite,Sohyun McElroy,Samantha R. Renusch,Dara Ditsworth,Clotilde Lagier-Tourenne,Richard A. G. Smith,John Ravits,Arthur H.M. Burghes,Pamela J. Shaw,Don W. Cleveland,Stephen J. Kolb,Brian K. Kaspar,Brian K. Kaspar +16 more
TL;DR: Easy production and expansion of i-astrocytes now enables rapid disease modeling and high-throughput drug screening to alleviate astrocyte-derived toxicity, suggesting a common mechanism of ALS.
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Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial.
Benjamin Rix Brooks,Ronald A. Thisted,Stanley H. Appel,Walter G. Bradley,Richard K. Olney,James Berg,Laura E. Pope,Richard A. G. Smith +7 more
TL;DR: In this paper, a multicenter, randomized, double-blind, controlled, parallel, three-arm study was conducted to test a defined combination of dextromethorphan hydrobromide (DM) and quinidine sulfate (Q) for the treatment of pseudobulbar affect in ALS.
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Human interleukin 4. The solution structure of a four-helix bundle protein.
Lorna J. Smith,Christina Redfield,Jonathan Boyd,G. M. P. Lawrence,R. G. Edwards,Richard A. G. Smith,Christopher M. Dobson +6 more
TL;DR: In this article, a dynamical simulated annealing protocol was used to calculate an ensemble of structures from an nmr data set of 1735 distance restraints, 101 φ angle restraints and 27 pairs of hydrogen bond restraints.
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Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis.
Hillel Panitch,Ronald A. Thisted,Richard A. G. Smith,Daniel Wynn,James Wymer,Anat Achiron,Timothy Vollmer,Raul N. Mandler,Dennis W. Dietrich,Malcolm Fletcher,Laura E. Pope,James Berg,Ariel Miller +12 more
TL;DR: To evaluate the efficacy and safety of DM/Q (capsules containing dextromethorphan [DM] and quinidine [Q]) compared with placebo, taken twice daily, for the treatment of pseudobulbar affect over a 12‐week period in multiple sclerosis patients.
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Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction.
Qi Peng,Ke Li,Katie Anderson,Conrad A. Farrar,Bao Lu,Richard A. G. Smith,Steven H. Sacks,Wuding Zhou +7 more
TL;DR: The findings suggest that the capacity of DCs for allostimulation depends on their ability to express, activate, and detect relevant complement components leading to C3aR signaling, which has implications for a wider range of immune responses in self-restricted T-cell priming.