Gottfried Baier

TL;DR: It is shown that Ras is activated following ligation of Fas on lymphoid lines, which suggests that ceramides acts as second messengers in Fas signaling via Ras and is necessary, but not sufficient, for subsequent apoptosis.

TL;DR: This novel TAM/Cbl-b inhibitory pathway shows that it might be possible to develop a ‘pill’ that awakens the innate immune system to kill cancer metastases, and the anticoagulant warfarin exerts anti-metastatic activity in mice via Cbl- b/TAM receptors in NK cells.

TL;DR: The results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling.

TL;DR: RNase protection assays and semiquantitative PCR analysis indicated that, although PKC theta transcripts are expressed ubiquitously, the highest levels are found in hematopoietic tissues and cell lines, including T cells and thymocytes, suggesting that it may play a role in signal transduction and growth regulatory pathways unique to these cells.

TL;DR: It is demonstrated that after CD3/CD28 engagement, deficiency of PKCθ primarily abrogates NFAT transactivation, suggesting that PKC θ plays a critical and nonredundant role in T cell receptor–induced NFAT activation.