M
Markus Heck
Researcher at University of Zurich
Publications - 2
Citations - 261
Markus Heck is an academic researcher from University of Zurich. The author has contributed to research in topics: Binding site & Ligand (biochemistry). The author has an hindex of 2, co-authored 2 publications receiving 243 citations.
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Journal ArticleDOI
Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
Katja Zerbe,Olena Pylypenko,Francesca Vitali,Weiwen Zhang,Severine Rouset,Markus Heck,Jan Wim Vrijbloed,Daniel Bischoff,Bojan Bister,Roderich D. Süssmuth,Stefan Pelzer,Wolfgang Wohlleben,John A. Robinson,Ilme Schlichting +13 more
TL;DR: Gene-inactivation studies point to the involvement of OxyB in catalyzing the first oxidative phenol coupling reaction during glycopeptide antibiotic biosynthesis, and OxyB exhibits the typical P450-fold.
Journal ArticleDOI
Oxidative phenol coupling reactions catalyzed by OxyB: a cytochrome P450 from the vancomycin producing organism. implications for vancomycin biosynthesis.
Katharina Woithe,Nina Geib,Katja Zerbe,Dong Bo Li,Markus Heck,Severine Fournier-Rousset,Odile Meyer,Francesca Vitali,Nobuatsu Matoba,Khaled Abou-Hadeed,John A. Robinson +10 more
TL;DR: It is shown that cross-linking of Hpg4 and Tyr6 by OxyB can occur in both hexapeptide- and heptapeptid-PCP conjugates, and it is possible that a linear heptAPEptide intermediate linked to PCP-7 in NRPS subunit-3 may also be transformed into monocyclic product.