Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
Katja Zerbe,Olena Pylypenko,Francesca Vitali,Weiwen Zhang,Severine Rouset,Markus Heck,Jan Wim Vrijbloed,Daniel Bischoff,Bojan Bister,Roderich D. Süssmuth,Stefan Pelzer,Wolfgang Wohlleben,John A. Robinson,Ilme Schlichting +13 more
TLDR
Gene-inactivation studies point to the involvement of OxyB in catalyzing the first oxidative phenol coupling reaction during glycopeptide antibiotic biosynthesis, and OxyB exhibits the typical P450-fold.About:
This article is published in Journal of Biological Chemistry.The article was published on 2002-12-06 and is currently open access. It has received 143 citations till now. The article focuses on the topics: Hemeprotein & Active site.read more
Citations
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Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.
TL;DR: Alkane hydroxylation proceeds by TSR,70-72,120 in which the HS mechanism is truly stepwise with a finite lifetime for the radical intermediate, whereas the LS mechanism is effectively concerted with an ultrashort lifetime forThe radical intermediate.
Journal ArticleDOI
Structure and Chemistry of Cytochrome P450
TL;DR: This review will concentrate on findings with P-450cam of the Pseudomonas putida camphor-5-exo-hydroxylase, and attention will be drawn to parallel and contrasting examples from other P- 450s as appropriate.
Journal ArticleDOI
Lessons from natural molecules
Jon Clardy,Christopher T. Walsh +1 more
TL;DR: Improvements in approaches for natural-product isolation, characterization and synthesis could be opening the door to a new era in the investigation of natural products in academia and industry.
Journal ArticleDOI
Glycopeptide and Lipoglycopeptide Antibiotics
Journal ArticleDOI
Natural Products Version 2.0: Connecting Genes to Molecules
TL;DR: This Perspective explores how connecting Nature's small molecules to the genes that encode them has sparked a renaissance in natural product research, focusing primarily on the biosynthesis of polyketides and non-ribosomal peptides.
References
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The Protein Data Bank
Helen M. Berman,John D. Westbrook,Zukang Feng,Gary L. Gilliland,Talapady N. Bhat,Helge Weissig,Ilya N. Shindyalov,Philip E. Bourne +7 more
TL;DR: The goals of the PDB are described, the systems in place for data deposition and access, how to obtain further information and plans for the future development of the resource are described.
Journal ArticleDOI
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination
Axel T. Brunger,Axel T. Brunger,Paul D. Adams,G M Clore,W. L. DeLano,Piet Gros,R.W. Grosse-Kunstleve,R.W. Grosse-Kunstleve,Jiansheng Jiang,J. Kuszewski,Michael Nilges,Navraj S. Pannu,Randy J. Read,Luke M. Rice,Thomas Simonson,Gregory L. Warren +15 more
TL;DR: The Crystallography & NMR System (CNS) as mentioned in this paper is a software suite for macromolecular structure determination by X-ray crystallography or solution nuclear magnetic resonance (NMR) spectroscopy.
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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
TL;DR: The MOLSCRIPT program as discussed by the authors produces plots of protein structures using several different kinds of representations, including simple wire models, ball-and-stick models, CPK models and text labels.
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Improved methods for building protein models in electron density maps and the location of errors in these models.
TL;DR: In this paper, the authors describe strategies and tools that help to alleviate this problem and simplify the model-building process, quantify the goodness of fit of the model on a per-residue basis and locate possible errors in peptide and side-chain conformations.
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