M
Markus Künzler
Researcher at ETH Zurich
Publications - 88
Citations - 3092
Markus Künzler is an academic researcher from ETH Zurich. The author has contributed to research in topics: Coprinopsis cinerea & Gene. The author has an hindex of 31, co-authored 79 publications receiving 2587 citations. Previous affiliations of Markus Künzler include University of Göttingen & Heidelberg University.
Papers
More filters
Journal ArticleDOI
Yeast Los1p Has Properties of an Exportin-Like Nucleocytoplasmic Transport Factor for tRNA
TL;DR: The homology between Los1p and the recently identified human exportin for tRNA is confirmed and the possibility of a role for Los1 p in nuclear export of tRNA in yeast is reinforced.
Journal ArticleDOI
Cell surface counter receptors are essential components of the unconventional export machinery of galectin-1
TL;DR: It is concluded that the β-galactoside binding site represents the primary targeting motif of galectins defining a galectin export machinery that makes use of β-Galactosid–containing surface molecules as export receptors for intracellular galECTin-1.
Journal ArticleDOI
Structure and Functional Analysis of the Fungal Galectin CGL2
P.J. Walser,Peter W. Haebel,Markus Künzler,David F. Sargent,Ursula Kües,Markus Aebi,Nenad Ban +6 more
TL;DR: The fundamental parameters responsible for selectivity by the fungal representative, CGL2, are dissected to reveal that this prototype galectin achieves increased substrate specificity by accommodating substituted oligosaccharides of the mammalian blood group A/B type in an extended binding cleft.
Journal ArticleDOI
Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis
Andreas Essig,Daniela Hofmann,Daniela Münch,Savitha Gayathri,Markus Künzler,Pauli T. Kallio,Hans-Georg Sahl,Gerhard Wider,Tanja Schneider,Markus Aebi +9 more
TL;DR: Copsin was bactericidal against a diversity of Gram-positive bacteria, including human pathogens such as Enterococcus faecium and Listeria monocytogenes and the unique structural properties of copsin make it a possible scaffold for new antibiotics.
Journal ArticleDOI
Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2
Alex Butschi,Alexander Walter Titz,Martin A. Wälti,Vincent Olieric,Katharina Paschinger,Katharina Nöbauer,Xiaoqiang Guo,Peter H. Seeberger,Iain B. H. Wilson,Markus Aebi,Michael O. Hengartner,Markus Künzler +11 more
TL;DR: Feeding a mushroom galectin to Caenorhabditis elegans inhibited development and reproduction and ultimately resulted in killing of this nematode, suggesting that fungal galectins play a role in the defense of fungi against predators by binding to specific glycoconjugates of these organisms.