M
Marlene Espinoza-Moraga
Researcher at University of Cape Town
Publications - 16
Citations - 570
Marlene Espinoza-Moraga is an academic researcher from University of Cape Town. The author has contributed to research in topics: Enantioselective synthesis & Imine. The author has an hindex of 8, co-authored 15 publications receiving 151 citations. Previous affiliations of Marlene Espinoza-Moraga include South African Medical Research Council & University of Talca.
Papers
More filters
Journal ArticleDOI
SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters
Peter Halfmann,Shun Iida,Kiyoko Iwatsuki-Horimoto,Tadashi Maemura,Maki Kiso,Suzanne M. Scheaffer,Tamarand L. Darling,Astha Joshi,Samantha Loeber,Gagandeep Singh,Stephanie L. Foster,Baoling Ying,James Brett Case,Zhenlu Chong,Bradley M. Whitener,Juan I. Moliva,Katharine Floyd,Michiko Ujie,Noriko Nakajima,Mutsumi Ito,R. Wright,Ryuta Uraki,Prajakta Warang,Matthew Gagne,Rongxiu Li,Yuko Sakai-Tagawa,Yanan Liu,Deanna Larson,Jorge E. Osorio,Juan P. Hernández-Ortiz,Amy R. Henry,Karl A Ciuoderis,Kelsey Florek,Mit Patel,Abby E. Odle,Lok-Yin Roy Wong,Allen C. Bateman,Zhongde Wang,Venkata Viswanadh Edara,John Franks,Trushar Jeevan,Thomas P. Fabrizio,Jennifer DeBeauchamp,Lisa Kercher,Patrick Seiler,Ana S. Gonzalez-Reiche,Emilia Mia Sordillo,Lauren A. Chang,Harm van Bakel,Viviana Simon,Bremy Alburquerque,Hala Alshammary,Angela Amoako,Shiraz Aslam,Radhika N. Banu,Cecilia Cognigni,Marlene Espinoza-Moraga,K. Farrugia,Adriana van de Guchte,Z. Khalil,Manon Laporte,Ignacio Mena,Alberto Paniz-Mondolfi,Jose Polanco,A.A. “Sonny” Rooker,L. Sominsky,Daniel C. Douek,Nancy J. Sullivan,Larissa B. Thackray,Hiroshi Ueki,Seiya Yamayoshi,Masaki Imai,Stanley Perlman,Richard J. Webby,Robert A. Seder,Mehul S. Suthar,Adolfo García-Sastre,Michael Schotsaert,Tadaki Suzuki,Adrianus C. M. Boon,Michael S. Diamond,Yoshihiro Kawaoka +81 more
TL;DR: In this paper , the authors evaluated the ability of several B.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters.
Journal ArticleDOI
Bioreduction of β-carboline imines to amines employing Saccharomyces bayanus
Marlene Espinoza-Moraga,Tania Petta,Marco Vasquez-Vasquez,V. Felipe Laurie,Luis A. B. Moraes,Leonardo S. Santos +5 more
TL;DR: In this article, β-Carboline imine reductions mediated by Saccharomyces bayanus have been described achieving moderate to good enantiomeric excesses of the amine products.
Journal ArticleDOI
In silico comparison of antimycobacterial natural products with known antituberculosis drugs.
TL;DR: The docking results suggest that scytoscalarol, an antibacterial and antifungal guanidine-bearing sesterterpene, can inhibit arabinosyltransferase Mtb EmbC, and the β-carboline alkaloids 8-hydroxymanzamine A and manzamines A can bind to the oxidoreductase of Mtb INHA.
Journal ArticleDOI
Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.
Marlene Espinoza-Moraga,Kawaljit Singh,Mathew Njoroge,Gurminder Kaur,John Okombo,Carmen de Kock,Pete Smith,Sergio Wittlin,Kelly Chibale,Kelly Chibale +9 more
TL;DR: A series of novel fusidic acid derivatives was synthesized by replacing the carboxylic acid group with various ester and amide groups and evaluated in vitro for their antiplasmodial activity against the chloroquine-sensitive NF54 and multidrug-resistant K1 strains of the malarial parasite Plasmodium falciparum.
Journal ArticleDOI
Palladium asymmetric reduction of β-carboline imines mediated by chiral auxiliaries assisted by microwave irradiation
TL;DR: An alternative synthetic approach for the introduction of chirality in β-carboline moiety through in situ reduction of N-acyliminium ion intermediates generated from imine 2 and chloroformate of 8-phenylmenthyl as chiral auxiliary was achieved.