Marta Martínez-García

TL;DR: Biophysical experiments showed that EBR1, a 29 nucleotide long highly repeated PQS in T. brucei, forms a stable G4 structure and G4 ligands based on carbohydrate conjugated naphthalene diimides that bind G4’s including hTel could bind E BR1 with selectivity versus dsDNA, which showed important antiparasitic activity.

TL;DR: It is reported herein that nonleishmanicidal concentrations of sitamaquine reverse miltefosine resistance in a multidrug resistance Leishmania tropica line that overexpresses LMDR1, and it is shown that ketoconazole, another oral leish manicidal drug known to interact with ABC transporters, is also able to reverseLMDR1-mediated milteFosinesine resistance, although with a lower efficiency than sitamquine.

TL;DR: Results show that trypanosomatid parasites rescue heme from endocytosed hemoglobin through endolysosomal HRG transporters, which could constitute novel drug targets.

TL;DR: Results indicateAS-48 kills the parasite through a mechanism involving clathrin-mediated endocytosis of VSG-bound AS-48 and the induction of autophagic-like cell death, and could be an attractive lead compound for the treatment of sleeping sickness and nagana.

TL;DR: Data is presented supporting a role for LmABCB3 in the biogenesis of cytosolic ISC, essential cofactors for cell viability in all three kingdoms of life and solid evidence suggesting that Lm ABCB3 is an essential gene is shown.