M
Martin Kery
Researcher at Slovak Academy of Sciences
Publications - 8
Citations - 148
Martin Kery is an academic researcher from Slovak Academy of Sciences. The author has contributed to research in topics: Tumor hypoxia & Pyruvate dehydrogenase kinase. The author has an hindex of 5, co-authored 8 publications receiving 93 citations. Previous affiliations of Martin Kery include Ohio State University & The Ohio State University Wexner Medical Center.
Papers
More filters
Journal ArticleDOI
Microenvironmental control of glucose metabolism in tumors by regulation of pyruvate dehydrogenase
TL;DR: A better understanding of PDC's enzymatic regulation in vivo and of the mechanisms of PDHK‐mediated malignant progression is necessary for the design of better PDHK inhibitors and the selection of patients most likely to benefit from such inhibitors.
Journal ArticleDOI
CAIX Regulates Invadopodia Formation through Both a pH-Dependent Mechanism and Interplay with Actin Regulatory Proteins.
Michaela Debreova,Lucia Csaderova,Monika Burikova,Lubomira Lukacikova,Ivana Kajanova,Olga Sedlakova,Martin Kery,Juraj Kopacek,Miriam Zatovicova,Jozef Bizik,Silvia Pastorekova,Eliska Svastova +11 more
TL;DR: In vivo localization of CAIX is demonstrated within invadopodia and gives rationale for its targeting during anti-metastatic therapy and confirms the key role of CAix in the metastatic process.
Journal ArticleDOI
Lactate stimulates CA IX expression in normoxic cancer cells
Elena Panisova,Martin Kery,Olga Sedlakova,Lucie Brisson,Michaela Debreova,Martina Sboarina,Pierre Sonveaux,Silvia Pastorekova,Eliska Svastova +8 more
TL;DR: By inducing CA IX, lactate can facilitate the maintenance of cancer cell aggressive behavior in normoxia and participation of both HIF-1 and specificity protein 1 (SP1) transcription factors is crucial for lactate-driven normoxic induction of the CA9 gene.
Journal ArticleDOI
CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia.
Martin Benej,Martin Benej,Eliska Svastova,Radivojka Banova,Juraj Kopacek,Adriana Gibadulinova,Martin Kery,Simona Arena,Andrea Scaloni,Monica Vitale,Nicola Zambrano,Ioanna Papandreou,Nicholas C. Denko,Silvia Pastorekova +13 more
TL;DR: Results indicate that in the absence of CA IX, reduction of pHi disrupts LDHA activity and hinders the cellular capacity to regenerate NAD+ and secrete protons to the extracellular space, andHypoxia-induced CA IX mediates adaptation to microenvironmental hypoxia and acidosis directly and indirectly by maintaining glycolysis-permissive intracellular milieu.
Journal ArticleDOI
Emerging strategies to target cancer metabolism and improve radiation therapy outcomes
Martin Kery,Ioanna Papandreou +1 more
TL;DR: There are opportunities to enhance the efficacy of radiotherapy by exploiting cell-inherent vulnerabilities and dynamic microenvironmental components of the tumor by exploiting metabolic pathways in the context of ionizing radiation responses.