M
Martin Valachovic
Researcher at Slovak Academy of Sciences
Publications - 24
Citations - 690
Martin Valachovic is an academic researcher from Slovak Academy of Sciences. The author has contributed to research in topics: Ergosterol & Sterol. The author has an hindex of 12, co-authored 24 publications receiving 606 citations. Previous affiliations of Martin Valachovic include Max F. Perutz Laboratories & Medical University of Vienna.
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Journal ArticleDOI
Transcription of the Yeast Iron Regulon Does Not Respond Directly to Iron but Rather to Iron-Sulfur Cluster Biosynthesis
TL;DR: It is demonstrated that transcription of FET3 and FTR1 genes does not respond directly to cytosolic iron but rather to the mitochondrial utilization of iron for the synthesis of iron-sulfur (Fe-S) clusters.
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Protein–protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis
TL;DR: It is suggested that Erg28p works as a transmembrane scaffold to tether Erg27p and possibly other C-4 demethylation proteins (Erg25p, Erg26p), forming a dem methylation complex in the endoplasmic reticulum.
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Anaerobiosis induces complex changes in sterol esterification pattern in the yeast Saccharomyces cerevisiae.
TL;DR: It is shown that complex changes in esterification of exogenously supplied sterols were also induced by anaerobiosis, indicating that sterol esters may fulfil different roles in aerobic and anaerobic cells.
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The role of ABC proteins Aus1p and Pdr11p in the uptake of external sterols in yeast: dehydroergosterol fluorescence study.
Peter Kohut,Daniel Wüstner,Lucia Hronská,Karl Kuchler,Ivan Hapala,Martin Valachovic,Martin Valachovic +6 more
TL;DR: It is demonstrated that the yeast cell wall is actively involved in binding and uptake of ergosterol-like sterols, and the entry of sterol molecules into plasma membrane is not spontaneous but requires assistance of two ABC (ATP-binding cassette) pumps--Aus1p or Pdr11p.
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Squalene is lipotoxic to yeast cells defective in lipid droplet biogenesis.
TL;DR: It is proved that accumulated squalene is lipotoxic to yeast cells if it cannot be efficiently sequestered in lipid droplets, which supports the hypothesis about the role ofSqualene in the fungicidal activity of terbinafine.