Martine Rothblatt

TL;DR: Developments indicate that a new paradigm, integrating multiple existing preservation approaches and new technologies that have flourished in the past 10 years, could transform preservation research.

TL;DR: A 57-year-old man with nonischemic cardiomyopathy who was dependent on venoarterial extracorporeal membrane oxygenation (ECMO) and was not a candidate for standard therapeutics, including a traditional allograft, received a heart from a genetically modified pig source animal that had 10 individual gene edits.

TL;DR: This first‐ever life‐saving cardiac xenotransplantation was the result of decades of work and close coordination by researchers in genetic engineering, animal cloning, immunology, ex vivo organ perfusion, and thoracic surgery.

TL;DR: Cooper et al. as discussed by the authors proposed a genome editing for pig heart xenotransplantation and achieved the first successful transplant of a genome-edited pig heart into a human, achieving a survival of up to 9 months.