M
Mary Lou Orcutt
Researcher at National Institutes of Health
Publications - 38
Citations - 1996
Mary Lou Orcutt is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Molecular probe & Hybridization probe. The author has an hindex of 10, co-authored 38 publications receiving 1925 citations.
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Journal ArticleDOI
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Laura S. Schmidt,Fuh Mei Duh,F. Chen,Takeshi Kishida,Gladys Glenn,Peter L. Choyke,Stephen W. Scherer,Zhengping Zhuang,Irina A. Lubensky,Michael Dean,Rando Allikmets,Abirami Chidambaram,Ulf S.R. Bergerheim,J. T. Feltis,C. Casadevall,A. Zamarron,M. Bernues,Stéphane Richard,C. J. M. Lips,McClellan M. Walther,Lap-Chee Tsui,Laura Geil,Mary Lou Orcutt,Thomas Stackhouse,J. Lipan,L. Slife,Hiltrud Brauch,Jochen Decker,G. Niehans,M. D. Hughson,Holger Moch,Stefan Storkel,Michael I. Lerman,W.M. Linehan,B. Zbar +34 more
TL;DR: The results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas.
Journal ArticleDOI
Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3.
Shigeto Hosoe,Hiltrud Brauch,Farida Latif,Gladys Glenn,Gambert Daniel,Sherri J. Bale,Peter L. Choyke,Michael B. Gorin,Edward H. Oldfield,Arlene Berman,Jack Goodman,Mary Lou Orcutt,K. Hampsch,John Dllisio,William S. Modi,Wesley McBride,Patrick Anglard,Gary B. Weiss,McClellan M. Walther,W. Marston Linehan,Michael I. Lerman,Berton Zbar +21 more
TL;DR: It is found that VHL was linked to RAF1, confirming previous observations, and to two polymorphic DNA markers, D 3S18 and D3S191, and should be useful in identifying asymptomatic gene carriers in VHL families and in guiding efforts at gene isolation.
Journal Article
Suppression of Growth of Renal Carcinoma Cells by the von Hippel-Lindau Tumor Suppressor Gene
F. Chen,Takeshi Kishida,Fuh-Mei Duh,Paul Renbaum,Mary Lou Orcutt,Laura S. Schmidt,Berton Zbar +6 more
TL;DR: Direct evidence is provided that the VHL gene product functions to suppress the growth of renal carcinoma cells and also provides a model for mapping the domains of the V HL protein important in suppressing tumor growth.
Journal Article
Chromosome 3p deletions in head and neck carcinomas: statistical ascertainment of allelic loss.
Farida Latif,M Fivash,Gladys Glenn,K. Tory,Mary Lou Orcutt,K. Hampsch,J. Delisio,Michael I. Lerman,J M Cowan,M A Beckett +9 more
TL;DR: The data demonstrate that chromosomes 3p allelic loss is a common event in head and neck cancers and suggest that chromosome 3p tumor suppressor genes contribute to the pathogenesis of these tumors.
Journal ArticleDOI
Germline and Somatic Mutations in the Tyrosine Kinase Domain of the MET Proto-Oncogene in Papillary Renal Carcinomas
Laura S. Schmidt,Fuh Mei Duh,F. Chen,Takeshi Kishida,Gladys Glenn,Peter L. Choyke,Stephen W. Scherer,Zhengping Zhuang,Irina A. Lubensky,Michael Dean,Rando Allikmets,Abirami Chidambaram,Ulf S.R. Bergerheim,J. T. Feltis,C. Casadevall,A. Zamarron,M. Bernues,Stéphane Richard,C. J. M. Lips,McClellan M. Walther,Lap-Chee Tsui,Laura Geil,Mary Lou Orcutt,Thomas Stackhouse,J. Lipan,L. Slife,Hiltrud Brauch,Jochen Decker,G. Niehans,M. D. Hughson,Holger Moch,Stefan Storkel,Michael I. Lerman,W.M. Linehan,B. Zbar +34 more
TL;DR: This paper found that missense mutations located in the tyrosine kinase domain of the MET gene in the germline of affected members of HPRC families and in a subset of sporadic papillary renal carcinomas.