J
Jochen Decker
Researcher at University of Mainz
Publications - 10
Citations - 2436
Jochen Decker is an academic researcher from University of Mainz. The author has contributed to research in topics: Missense mutation & Genotype. The author has an hindex of 8, co-authored 10 publications receiving 2338 citations. Previous affiliations of Jochen Decker include National Institutes of Health.
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Journal ArticleDOI
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Laura S. Schmidt,Fuh Mei Duh,F. Chen,Takeshi Kishida,Gladys Glenn,Peter L. Choyke,Stephen W. Scherer,Zhengping Zhuang,Irina A. Lubensky,Michael Dean,Rando Allikmets,Abirami Chidambaram,Ulf S.R. Bergerheim,J. T. Feltis,C. Casadevall,A. Zamarron,M. Bernues,Stéphane Richard,C. J. M. Lips,McClellan M. Walther,Lap-Chee Tsui,Laura Geil,Mary Lou Orcutt,Thomas Stackhouse,J. Lipan,L. Slife,Hiltrud Brauch,Jochen Decker,G. Niehans,M. D. Hughson,Holger Moch,Stefan Storkel,Michael I. Lerman,W.M. Linehan,B. Zbar +34 more
TL;DR: The results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas.
Journal ArticleDOI
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.
Laura S. Schmidt,Kerstin Junker,Noboru Nakaigawa,T. Kinjerski,Gregor Weirich,M. Miller,Irina A. Lubensky,Hartmut P. H. Neumann,Hiltrud Brauch,Jochen Decker,Cathy D. Vocke,J. A. Brown,Robert B. Jenkins,Stéphane Richard,Ulf S.R. Bergerheim,Bernard Gerrard,Michael Dean,W. M. Linehan,Berton Zbar +18 more
TL;DR: The low frequency of MET mutations in noninherited papillary renal carcinomas (PRC) suggests that non inherited PRC may develop by a different mechanism than hereditary papillary kidneys carcinoma.
Journal ArticleDOI
Association of the P-Glycoprotein Transporter MDR1C3435T Polymorphism with the Susceptibility to Renal Epithelial Tumors
M. Siegsmund,Ulrich Brinkmann,Elke Schäffeler,Gregor Weirich,Matthias Schwab,Michel Eichelbaum,Peter Fritz,Oliver Burk,Jochen Decker,Peter Alken,Uwe Rothenpieler,Reinhold Kerb,Sven Hoffmeyer,Hiltrud Brauch +13 more
TL;DR: Evidence is provided for PGP to influence the susceptibility to develop renal epithelial tumors by virtue of its MDR1(C3435T) polymorphism and changes in expression.
Journal ArticleDOI
Influence of the RNA-Binding Protein HuR in pVHL-Regulated p53 Expression in Renal Carcinoma Cells
Stefanie Galbán,Jennifer L. Martindale,Krystyna Mazan-Mamczarz,Isabel López de Silanes,Jinshui Fan,Wengong Wang,Jochen Decker,Myriam Gorospe +7 more
TL;DR: A role for pVHL in elevating p53 expression is supported, HuR is implicate in enhancing VHL-mediated p53 translation, and VHL upregulation may contribute to pV HL's tumor suppressive functions in renal cell carcinoma are suggested.
Journal ArticleDOI
von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays.
Stefanie Galbán,Jinshui Fan,Jennifer L. Martindale,Chris Cheadle,Bryan E. Hoffman,Michael P. Woods,Gretchen Temeles,Jürgen Brieger,Jochen Decker,Myriam Gorospe +9 more
TL;DR: A novel function is uncovered for the pVHL tumor suppressor protein as regulator of protein translation through the TNF-α 3′-untranslated region.