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Irina A. Lubensky
Researcher at National Institutes of Health
Publications - 121
Citations - 14966
Irina A. Lubensky is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Multiple endocrine neoplasia & MEN1. The author has an hindex of 57, co-authored 121 publications receiving 14423 citations. Previous affiliations of Irina A. Lubensky include Technische Universität München & Science Applications International Corporation.
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Journal ArticleDOI
Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1
Settara C. Chandrasekharappa,Siradanahalli C. Guru,Pachiappan Manickam,Shodimu Emmanuel Olufemi,Francis S. Collins,Michael R. Emmert-Buck,Larisa V. Debelenko,Zhengping Zhuang,Irina A. Lubensky,Lance A. Liotta,Judy S. Crabtree,Yingping Wang,Bruce A. Roe,Jane M. Weisemann,Mark S. Boguski,Sunita K. Agarwal,Mary Beth Kester,Young Sik Kim,Christina Heppner,Qihan Dong,Allen M. Spiegel,A. Lee Burns,Stephen J. Marx +22 more
TL;DR: The identification of MEN1 will enable improved understanding of the mechanism of endocrine tumorigenesis and should facilitate early diagnosis of multiple endocrine neoplasia-type 1.
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Mutations of the VHL tumour suppressor gene in renal carcinoma
James R. Gnarra,K. Tory,Yongkai Weng,Laura S. Schmidt,Ming-Hui Wei,Haiyan I. Li,Farida Latif,S. Liu,F. Chen,Fuh Mei Duh,Irina A. Lubensky,D. R. Duan,C. Florence,Rudy Pozzatti,M. M. Walther,Neil H. Bander,H.B. Grossman,Hiltrud Brauch,S. Pomer,James D. Brooks,William B. Isaacs,Michael I. Lerman,Berton Zbar,W. M. Linehan +23 more
TL;DR: The identification of VHL mutations in a majority of localized and advanced sporadic renal carcinomas and in a second form of hereditary renal carcinoma indicates that the VHL gene plays a critical part in the origin of this malignancy.
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Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Laura S. Schmidt,Fuh Mei Duh,F. Chen,Takeshi Kishida,Gladys Glenn,Peter L. Choyke,Stephen W. Scherer,Zhengping Zhuang,Irina A. Lubensky,Michael Dean,Rando Allikmets,Abirami Chidambaram,Ulf S.R. Bergerheim,J. T. Feltis,C. Casadevall,A. Zamarron,M. Bernues,Stéphane Richard,C. J. M. Lips,McClellan M. Walther,Lap-Chee Tsui,Laura Geil,Mary Lou Orcutt,Thomas Stackhouse,J. Lipan,L. Slife,Hiltrud Brauch,Jochen Decker,G. Niehans,M. D. Hughson,Holger Moch,Stefan Storkel,Michael I. Lerman,W.M. Linehan,B. Zbar +34 more
TL;DR: The results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the MET protein and papillary renal carcinomas.
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Novel mutations of the MET proto-oncogene in papillary renal carcinomas.
Laura S. Schmidt,Kerstin Junker,Noboru Nakaigawa,T. Kinjerski,Gregor Weirich,M. Miller,Irina A. Lubensky,Hartmut P. H. Neumann,Hiltrud Brauch,Jochen Decker,Cathy D. Vocke,J. A. Brown,Robert B. Jenkins,Stéphane Richard,Ulf S.R. Bergerheim,Bernard Gerrard,Michael Dean,W. M. Linehan,Berton Zbar +18 more
TL;DR: The low frequency of MET mutations in noninherited papillary renal carcinomas (PRC) suggests that non inherited PRC may develop by a different mechanism than hereditary papillary kidneys carcinoma.
Journal ArticleDOI
Cyclophosphamide-Induced Cystitis and Bladder Cancer in Patients with Wegener Granulomatosis
Cheryl Talar-Williams,Y M Hijazi,M. M. Walther,W. M. Linehan,Claire W. Hallahan,Irina A. Lubensky,Gail S. Kerr,Gary S. Hoffman,Anthony S. Fauci,Michael C. Sneller +9 more
TL;DR: The incidence, clinical manifestations, and natural history of cyclophosphamide-mediated urotoxicity in a cohort of patients with Wegener granulomatosis are described and recommendations for surveillance are discussed.