Y
Yuji Kakazu
Researcher at Keio University
Publications - 9
Citations - 3568
Yuji Kakazu is an academic researcher from Keio University. The author has contributed to research in topics: Mass spectrometry & Capillary electrophoresis. The author has an hindex of 7, co-authored 9 publications receiving 3084 citations.
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Journal ArticleDOI
MassBank: a public repository for sharing mass spectral data for life sciences.
Hisayuki Horai,Masanori Arita,Masanori Arita,Shigehiko Kanaya,Yoshito Nihei,Tasuku Ikeda,Kazuhiro Suwa,Yuya Ojima,Kenichi Tanaka,Satoshi Tanaka,Ken Aoshima,Yoshiya Oda,Yuji Kakazu,Miyako Kusano,Takayuki Tohge,Fumio Matsuda,Yuji Sawada,Masami Yokota Hirai,Hiroki Nakanishi,Kazutaka Ikeda,Naoshige Akimoto,Takashi Maoka,Hiroki Takahashi,Takeshi Ara,Nozomu Sakurai,Hideyuki Suzuki,Daisuke Shibata,Steffen Neumann,Takashi Iida,Ken Tanaka,Kimito Funatsu,Fumito Matsuura,Tomoyoshi Soga,Ryo Taguchi,Kazuki Saito,Takaaki Nishioka +35 more
TL;DR: MassBank is the first public repository of mass spectra of small chemical compounds for life sciences and provides a merged spectrum for each compound prepared by merging the analyzed ESI-MS(2) data on an identical compound under different collision-induced dissociation conditions.
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Multiple high-throughput analyses monitor the response of E. coli to perturbations.
Nobuyoshi Ishii,Kenji Nakahigashi,Tomoya Baba,Tomoya Baba,Martin Robert,Tomoyoshi Soga,Akio Kanai,Takashi Hirasawa,Miki Naba,Kenta Hirai,Aminul Hoque,Pei Yee Ho,Yuji Kakazu,Kaori Sugawara,Saori Igarashi,Satoshi Harada,Takeshi Masuda,Naoyuki Sugiyama,Takashi Togashi,Miki Hasegawa,Yuki Takai,Katsuyuki Yugi,Kazuharu Arakawa,Nayuta Iwata,Yoshihiro Toya,Yoichi Nakayama,Takaaki Nishioka,Takaaki Nishioka,Kazuyuki Shimizu,Kazuyuki Shimizu,Hirotada Mori,Hirotada Mori,Masaru Tomita +32 more
TL;DR: E. coli seems to use complementary strategies that result in a metabolic network robust against perturbations, and actively regulated enzyme levels to maintain a stable metabolic state in response to changes in growth rate.
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Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption.
Tomoyoshi Soga,Richard Baran,Makoto Suematsu,Yuki Ueno,Satsuki Ikeda,Tadayuki Sakurakawa,Yuji Kakazu,Takamasa Ishikawa,Martin Robert,Takaaki Nishioka,Masaru Tomita +10 more
TL;DR: A metabolome differential display method based on capillary electrophoresis time-of-flight mass spectrometry to profile liver metabolites following acetaminophen-induced hepatotoxicity finds that serum ophthalmate is a sensitive indicator of hepatic GSH depletion, and may be a new biomarker for oxidative stress.
Journal ArticleDOI
Measurement of internal body time by blood metabolomics
Yoichi Minami,Takeya Kasukawa,Yuji Kakazu,Masayuki Iigo,Masahiro Sugimoto,Masahiro Sugimoto,Satsuki Ikeda,Akira Yasui,Gijsbertus T. J. van der Horst,Tomoyoshi Soga,Hiroki R. Ueda +10 more
TL;DR: The results suggest the potential for metabolomics-based detection of BT (“metabolite-timetable method”), which will lead to the realization of chronotherapy and personalized medicine.
Journal ArticleDOI
Qualitative and quantitative analysis of amino acids by capillary electrophoresis‐electrospray ionization‐tandem mass spectrometry
TL;DR: This approach is useful for the simultaneous, selective, quantitative, and reproducible analysis of amino acids in physiological and biological samples that contain various kinds of matrices.