M
Masakazu Sakai
Researcher at Kumamoto University
Publications - 54
Citations - 2118
Masakazu Sakai is an academic researcher from Kumamoto University. The author has contributed to research in topics: Scavenger receptor & Macrophage. The author has an hindex of 26, co-authored 54 publications receiving 2078 citations.
Papers
More filters
Journal ArticleDOI
Intravenous Injection of Rabbit Apolipoprotein A-I Inhibits the Progression of Atherosclerosis in Cholesterol-Fed Rabbits
Akira Miyazaki,Shin Sakuma,Wataru Morikawa,Takanori Takiue,Fumio Miake,Tsuyoshi Terano,Masakazu Sakai,Hideki Hakamata,Yu-Ichiro Sakamoto,Makoto Naito,Yingmao Ruan,Kiyoshi Takahashi,Takao Ohta,Seikoh Horiuchi +13 more
TL;DR: The present study provided the first evidence for the antiatherogenic effect of homologous and apoA-I on the progression of atherosclerosis in cholesterol-fed rabbits.
Journal ArticleDOI
Lysophosphatidylcholine plays an essential role in the mitogenic effect of oxidized low density lipoprotein on murine macrophages.
Masakazu Sakai,Akira Miyazaki,Hideki Hakamata,T Sasaki,S Yui,M Yamazaki,Motoaki Shichiri,S Horiuchi +7 more
TL;DR: Results suggest that lyso-PC may play an essential role in the mitogenic activity of Ox-LDL and that the growth-stimulating effect of acetyl-LD lysophosphatidylcholine on murine resident macrophages was negligibly weak.
Journal ArticleDOI
Two Intracellular Signaling Pathways for Activation of Protein Kinase C Are Involved in Oxidized Low-Density Lipoprotein–Induced Macrophage Growth
Takeshi Matsumura,Masakazu Sakai,Shozo Kobori,Takeshi Biwa,Toru Takemura,Hirofumi Matsuda,Hideki Hakamata,Seikoh Horiuchi,Motoaki Shichiri +8 more
TL;DR: The results suggest the presence of two intracellular signaling pathways for activation of PKC, a rise in calcium that was mediated by pertussis toxin-sensitive G protein and the internalization of lysophosphatidylcholine through the scavenger receptors.
Journal ArticleDOI
The Scavenger Receptor Serves as a Route for Internalization of Lysophosphatidylcholine in Oxidized Low Density Lipoprotein-induced Macrophage Proliferation
Masakazu Sakai,Akira Miyazaki,Hideki Hakamata,Tatsuhiko Kodama,Hiroshi Suzuki,Shozo Kobori,Motoaki Shichiri,Seikoh Horiuchi +7 more
TL;DR: The results suggest that the MSR is an important and efficient internalization pathway for lyso-PC in Ox-LDL-induced macrophage growth.
Journal ArticleDOI
Cost-effectiveness of intensive insulin therapy for type 2 diabetes: a 10-year follow-up of the Kumamoto study.
Nakayasu Wake,Akinori Hisashige,Takafumi Katayama,Hideki Kishikawa,Yasuo Ohkubo,Masakazu Sakai,Eiichi Araki,Motoaki Shichiri +7 more
TL;DR: Economic evaluation of a randomized controlled trial on the prevention of diabetes complications in Japan shows that MIT is more beneficial than CIT in both cost and effectiveness, and is recommended for the treatment of type 2 diabetic patients who require insulin therapy as early as possible.