Masashi Horiguchi

TL;DR: It is shown that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone, which suggests interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status.

TL;DR: It is demonstrated that the Hes1-mediated Notch pathway is required for region-appropriate specification of pancreas in the developing foregut endoderm through regulation of Ptf1a expression, providing novel insight into the pathogenesis of ectopic Pancreas development in a mouse model.

TL;DR: The dosage of PTF1a is crucial for pancreas specification, growth, total β-cell number, islet morphogenesis, and endocrine function, and the results suggest that some neonatal diabetes may be caused by mutation or single nucleotide polymorphisms in the Ptf1a gene.

TL;DR: Pdx1 is required for proper development of the major duodenal papilla, peribiliary glands, and mucin-producing cells in the common bile duct and for maintenance of the periampullary duodnal epithelial cells during perinatal period.

TL;DR: It is suggested that Hes1-mediated Notch activity determines the plasticity of adult pancreatic duct cells and that there may exist a dosage requirement of Sox9 for keeping the duct cell identity in the adult pancreas.