Michiya Kawaguchi

TL;DR: It is shown that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone, which suggests interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status.

TL;DR: In vitro studies demonstrated that SDF-1 significantly increased the migration ability of AsPC-1 and HUVECs, and these effects were inhibited by CXCR4 antagonist T22, and that the coculture system with MRC-9 also increased the Migration ability of CFPAC-1 cells, and this effect was significantly inhibited by T22.

TL;DR: Repetitive systemic exposure to high concentrations of curcumin achieved by Theracurmin® did not increase the incidence of adverse events in cancer patients receiving gemcitabine-based chemotherapy.

TL;DR: Examining expression analysis in pancreatic cancer tissue demonstrated involvement of alphaVbeta3 integrin in lymph node metastasis rather than peripancreatic invasion, and MMP-2 activation is linked, at least in part, to the expression of integrin alphaV beta3 of pancreaticcancer cells.

TL;DR: METH-1, which was initially reported to have a potent antiangiogenic effect, does not seem to be a predominant determinant of tumor vascularity in pancreatic cancer, and rather seems to be involved in progression of pancreaticcancer through local invasion and lymph node metastasis.