Masayuki Kuraoka

TL;DR: Testing the regulation and role of glucose uptake and metabolism in the proliferation and Ab production of control, anergic, and autoimmune-prone B cells shows that activated B cells require Glut1-dependent metabolic reprogramming to support proliferation andAb production that is distinct from T cells and that this glycolytic reprograming is regulated in tolerance.

TL;DR: This work explored the population dynamics of genetically diverse GC responses to two complex antigens-Bacillus anthracis protective antigen and influenza hemagglutinin-in which B cells competed both intra- and interclonally for distinct epitopes.

TL;DR: It is shown that alum cannot elicit reactive neutrophilias in IL-1R type I (IL-1RI)−/− mice, whereas other inflammatory responses, including eosinophilia and Ab production, remain intact.

TL;DR: Analysis of single memory B cells from immunized human donors has led to characterize a previously unrecognized epitope of influenza hemagglutinin (HA) that is immunogenic in humans and conserved among influenza subtypes.

TL;DR: It is found that glycan addition changed the initially diverse antibody repertoire into an epitope-focused, genetically restricted response, which has potential implications for next-generation viral vaccines aimed at directing B cell responses to preferred epitope(s).