G
Garnett Kelsoe
Researcher at Duke University
Publications - 235
Citations - 20685
Garnett Kelsoe is an academic researcher from Duke University. The author has contributed to research in topics: Antibody & Germinal center. The author has an hindex of 75, co-authored 230 publications receiving 19000 citations. Previous affiliations of Garnett Kelsoe include Johns Hopkins University & University of Maryland, Baltimore.
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Journal ArticleDOI
Intraclonal generation of antibody mutants in germinal centres
TL;DR: Direct evidence is reported for direct evidence that antigen-induced proliferation of B cells at another site, periarteriolar lymphocyte sheath-associated foci, was not associated with somatic hypermutation, and most represent cells of distinct B-cell clones which expanded locally, generating somatic antibody mutants at high rate.
Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.
TL;DR: It is suggested that foci may represent regions of predominantly interclonal competition for antigen among unmutated B cells, while germinal centers are sites of intraclonal clonal competition between mutated sister lymphocytes.
Journal Article
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
TL;DR: The findings suggest that the costimulatory roles of CD40: CD40L and B7-2 differ in the GC; administration of anti-CD40L abrogates an established GC reaction, whereas Ab to B 7-2 suppresses Ig hypermutation and entry into the B cell memory compartment.
Journal ArticleDOI
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.
Joshy Jacob,Garnett Kelsoe +1 more
TL;DR: In the genetically restricted response that follows immunization with (4-hydroxy-3-nitrophenyl)acetyl coupled to protein carriers, two distinct populations of B cells are observed in the spleens of C57BL/6 mice.