T
Thomas B. Kepler
Researcher at Boston University
Publications - 209
Citations - 18839
Thomas B. Kepler is an academic researcher from Boston University. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 67, co-authored 204 publications receiving 17142 citations. Previous affiliations of Thomas B. Kepler include University of Delaware & Brandeis University.
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Journal ArticleDOI
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
Hua-Xin Liao,Rebecca M. Lynch,Tongqing Zhou,Feng Gao,Feng Gao,S. Munir Alam,S. Munir Alam,Scott D. Boyd,Andrew Fire,Krishna M. Roskin,Chaim A. Schramm,Zhenhai Zhang,Jiang Zhu,Lawrence Shapiro,Lawrence Shapiro,Nisc Comparative Sequencing Program,James C. Mullikin,Sandrasegaram Gnanakaran,Peter T. Hraber,Kevin Wiehe,Kevin Wiehe,Garnett Kelsoe,Garnett Kelsoe,Guang Yang,Guang Yang,Shi-Mao Xia,Shi-Mao Xia,David C. Montefiori,David C. Montefiori,Robert Parks,Robert Parks,Krissey E. Lloyd,Krissey E. Lloyd,Richard M. Scearce,Richard M. Scearce,Kelly A. Soderberg,Kelly A. Soderberg,Myron S. Cohen,Gift Kamanga,Mark K. Louder,Lillian Tran,Yue Chen,Yue Chen,Fangping Cai,Fangping Cai,Sheri Chen,Sheri Chen,Stephanie Moquin,Xiulian Du,M. Gordon Joyce,Sanjay Srivatsan,Baoshan Zhang,Anqi Zheng,George M. Shaw,Beatrice H. Hahn,Thomas B. Kepler,Bette T. Korber,Peter D. Kwong,John R. Mascola,Barton F. Haynes,Barton F. Haynes +60 more
TL;DR: The isolation, evolution and structure of a broadly neutralizing antibody from an African donor followed from the time of infection and its co-crystal structure revealed a new loop-based mechanism of CD4-binding-site recognition.
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Stochasticity in Transcriptional Regulation: Origins, Consequences, and Mathematical Representations
TL;DR: Stochastic bistability where the deterministic equations predict monostability and vice-versa is found; among them, bifurcations driven solely by changing the rate of operator fluctuations even as the underlying deterministic system remains unchanged are found.
PatentDOI
Focused evolution of hiv-1 neutralizing antibodies revealed by crystal structures and deep sequencing
TL;DR: In this article, the authors used X-ray crystallography and 454 pyrosequencing to characterize additional antibodies from HIV-1-infected individuals, revealing a convergent mode of binding of different antibodies to the same CD4-binding-site epitope.
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Invertebrate immune systems--not homogeneous, not simple, not well understood.
TL;DR: Data suggest that novel immune capabilities will be found among the different invertebrate phyla, and a model is presented that supports the adaptive value of diversified non‐self recognition molecules in invertebrates.
Journal Article
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
TL;DR: The findings suggest that the costimulatory roles of CD40: CD40L and B7-2 differ in the GC; administration of anti-CD40L abrogates an established GC reaction, whereas Ab to B 7-2 suppresses Ig hypermutation and entry into the B cell memory compartment.