Showing papers by "Massimo Antonelli published in 2006"
TL;DR: Robust evidence now supports the use of CPAP and NPPV in ACPE as both techniques decrease NETI and mortality compared to SMT and none shows increased AMI risk.
Abstract: Introduction
Continuous positive airway pressure ventilation (CPAP) and non-invasive positive pressure ventilation (NPPV) are accepted treatments in acute cardiogenic pulmonary edema (ACPE). However, it remains unclear whether NPPV is better than CPAP in reducing the need for endotracheal intubation (NETI) rates, mortality and other adverse events. Our aim was to review the evidence about the efficacy and safety of these two methods in ACPE management.
233 citations
TL;DR: In this paper, the first observation of quantum interference in the process ϕ→KSKL→π+π−π +π + π−π+δ−π−δ t was made using the KLOE detector at the Frascati e+e− collider DAΦNE.
81 citations
TL;DR: In this article, the spectrum of π + π − invariant mass in a sample of 6.7 × 10 5 e + e − → π+ π− γ events with the photon at large polar angle ( θ γ > 45 ° ) at a centre of mass energy s around the ϕ mass.
74 citations
Journal Article•
73 citations
TL;DR: In this paper, the first measurements of the charge asymmetry and form-factor slope for semileptonic K S decays were obtained, which is compatible with the requirements of CPT invariance.
67 citations
TL;DR: NPPV was a safe and effective first-line therapeutic approach in hypoxemic ARF children/infants with neuromuscular disease and the new helmet interface represents a promising tool for noninvasive ventilation in older children.
Abstract: Background: Over a 36-month study period, 10 nonconsecutive neuromuscular pediatric patients (6 infants, mean age 10.16 months, and 4 children, mean age 9.3 years) presenting with a
57 citations
TL;DR: In this article, a measurement of the Kπ vector current form factor parameters for the decay K L → π ± e ∓ ν was presented, where λ + = ( 28.6 ± 0.4 ) × 10 −3 for a linear fit, and λ+ + =( 25.5 ± 1.5 −3 )−1 for a quadratic fit.
50 citations
TL;DR: In this paper, the integrated luminosity of the e+e-collider DAΦNE, the Frascati φ-factory was measured with the KLOE detector selecting large angle Bhabha scattering events and normalizing them to the effective cross section.
Abstract: We describe the method of measuring the integrated luminosity of the e+e- collider DAΦNE, the Frascati φ-factory. The measurement is done with the KLOE detector selecting large angle Bhabha scattering events and normalizing them to the effective cross section. The e+e-→e+e-(γ) cross section is calculated using different event generators which account for the \(\mathcal{O}(\alpha)\) radiative initial and final state corrections, and the φ resonance contribution. The accuracy of the measurement is 0.6%, where 0.3% comes from systematic errors related to the event counting and 0.5% from theoretical evaluations of the cross section.
47 citations
TL;DR: The year in review in intensive care medicine, 2005: infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury.
Abstract: Peter Andrews Elie Azoulay Massimo Antonelli Laurent Brochard Christian Brun-Buisson Geoffrey Dobb Jean-Yves Fagon Herwig Gerlach Johan Groeneveld Jordi Mancebo Philipp Metnitz Stefano Nava Jerome Pugin Michael Pinsky Peter Radermacher Christian Richard Robert Tasker Year in review in intensive care medicine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury
38 citations
TL;DR: In edematous brain close to a posttraumatic hemorrhage the levels of vancomycin do not differ from that in healthy subjects, while subcutaneous interstitial levels were effective for clinical use.
Abstract: To evaluate the concentrations of vancomycin in the cerebral interstitial fluid after intravenous administration by multiple boli. Prospective non randomized study University hospital general ICU Four patients undergone to craniotomy for evacuation of cerebral posttraumatic hemorrhage, who developed pneumonia 4–7 days from the injury Two microdialysis catheters were placed in each patient: one in the edematous brain surrounding the focal lesion and one in the subcutaneous tissue of abdomen. Levels of vancomycin were measured in serum and in the microdialysates samples. Plasmatic concentration of 10–15 μg/ml in the trough level was obtained after four administrations of vancomycin. Levels of vancomycin in the
subcutaneous tissue was above minimum inhibitory concentrations in all patients after the second administration. Mean serum/brain ratio was 8%. Cerebral interstitial concentration of vancomycin was never above minimum inhibitory concentrations; its maximum value was 1.2 μg/ml. In edematous brain close to a posttraumatic hemorrhage the levels of vancomycin do not differ from that in healthy subjects. At these plasmatic concentrations cerebral interstitial levels of vancomycin were insufficient while subcutaneous interstitial levels were effective for clinical use.
25 citations
TL;DR: In this article, the authors used a sample of over 400 million φ→KSKL decays produced during the years 2001 and 2002 at the DAΦNE e+e- collider, and measured the ratio RS π = 2.2555±0.0054, reducing the total error by a factor of three.
Abstract: Using a sample of over 400 million φ→KSKL decays produced during the years 2001 and 2002 at the DAΦNE e+e- collider, the ratio RS
π=Γ(KS→π+π-(γ))/Γ(KS→π0π0) has been measured with the KLOE detector. The result is RS
π=2.2555±0.0012stat±0.0021corr-stat±0.0050syst, which is in good agreement with the previously published result based on the KLOE data sample from the year 2000. The average of the KLOE results is RS
π=2.2549±0.0054, reducing the total error by a factor of three, to 0.25%.
TL;DR: This review intends to summarize all articles published in Intensive Care Medicine in 2005, grouped by specific topics.
Abstract: This review intends to summarize all articles published in Intensive Care Medicine in 2005, grouped by specific topics.
TL;DR: The absolute branching ratio of the K+ -> pi(+) pi(-) pi (+) (gamma) decay, including of final-state radiation, has been measured using similar to 17 million tagged K+ mesons collected with the KLOE detector at DA Phi NE, the Frascati phi-factory as mentioned in this paper.
TL;DR: In this article, two string-based tunable colour reconnection models, one implemented in JETSET (the GAL model), the other implemented in ARIADNE, are compared.
Abstract: Hadronic Z decays into three jets are used to test QCD models of colour reconnection (CR). A sensitive quantity is the rate of gluon jets with a gap in the particle rapidity distribution and zero jet charge. Gluon jets are identified by either energy-ordering or by tagging two b-jets. The rates predicted by two string-based tunable CR models, one implemented in JETSET (the GAL model), the other in ARIADNE, are too high and disfavoured by the data, whereas the rates from the corresponding non-CR standard versions of these generators are too low. The data can be described by the GAL model assuming a small value for the R0 parameter in the range 0.01-0.02.
TL;DR: It is suggested that PDEIII inhibitors may be useful in restoring spontaneous circulation in cardiac arrest associated with beta‐blocker administration when standard ALS is ineffective.
Abstract: We report two clinical cases of cardiac arrest, the former due to an adverse effect of intravenous (i.v.) propranolol in a patient with systemic sclerosis, the latter from a propranolol suicidal overdose. In both cases, conventional advanced life support (ALS) was ineffective but both patients eventually responded to the administration of enoximone, a phosphodiesterase III (PDE III) inhibitor. After the arrest, both patients regained consciousness and were discharged home. The chronotropic and inotropic effects of PDE III inhibitors are due to inhibition of intracellular PDEIII and are therefore unaffected by beta-blockers. These cases suggest that PDEIII inhibitors may be useful in restoring spontaneous circulation in cardiac arrest associated with beta-blocker administration when standard ALS is ineffective.
TL;DR: This review intends to summarize all articles published in Intensive Care Medicine in2005, grouped by specific topics.
Abstract: Received: 8 January 2006Accepted: 8 January 2006© Springer-Verlag 2006This review intends tosummarize all articlespublished in Intensive Care Medicine in2005, grouped by specific topics.L. Brochard (✉) · C. Brun-BuissonAP-HP, Hopital Henri Mondor,Reanimation Medicale,INSERM U 615, Universite, Paris 12,Francee-mail: laurent.brochard@hmn.aphp.frTel.: +33-1-49812545Fax: +33-1-42079943P. AndrewsWestern General Hospital,Intensive Care Unit,Edinburgh, UKE. AzoulaySaint Louis Hospital,Intensive Care Unit,Paris, FranceM. AntonelliUniversita Cattolica del Sacro Cuore,Department of Intensive Cureand Anesthesiology,Rome, ItalyG. DobbRoyal Perth Hospital,Intensive Care Unit,Perth, AustraliaJ.-Y. FagonEuropean Georges Pompidou Hospital,Intensive Care Unit,Paris, FranceH. GerlachVivantes-Klinikum Neukoelln,Department of Anesthesiology,Berlin, GermanyJ. GroeneveldVUMC, Intensive Care Unit,Amsterdam, The NetherlandsJ. ManceboHospital Sant Pau,Intensive Care Unit,Barcelona, SpainP. MetnitzUniversity Hospital of Vienna,Department of Anesthesia and GeneralIntensive Care Medicine,Vienna, AustriaS. NavaFondazione S. Maugeri,Intensive Care Unit,Pavia, ItalyM. PinskyUniversity of Pittsburgh Medical Center,Intensive Care Unit,Pittsburgh Pa., USAP. RadermacherUniversity Medical School of Ulm,Department of Anesthesia,Ulm, GermanyC. RichardUniversity Hospital of Le Kremlin-Bicetre,Intensive Care Unit,Le Kremlin Bicetre, FranceR. TaskerAddenbrook’s Hospital,Pediatric Intensive Care Unit,Cambridge, UKJ. PuginUniversity Hospital of Geneva,Intensive Care Unit,Geneva, Switzerland
01 Dec 2006
TL;DR: The analysis of antibiotics’ concentration by microdialysis has several limitations, related mainly to the recovery of the substance in the dialysate, the position of the probe, the diffusion of the antibiotic in the tissue, and the technique of the analysis in the microdialytic sample.
Abstract: Sir: We appreciate the interest of Magnoni et al. in our study, as well as the opportunity to clarify their comment. We agree that the analysis of antibiotics’ concentration by microdialysis has several limitations, related mainly to the recovery of the substance in the dialysate, the position of the probe, the diffusion of the antibiotic in the tissue, and the technique of the analysis in the microdialytic sample. Nevertheless, it has two major strengths:
01 Jan 2006
TL;DR: Although application of non-invasive CPAP cannot be generally recommended in the early stage of hypoxemic acute respiratory failure related to ALI/ARDS or pneumonia, CPAP may be beneficial in high-risk, immunocompromised patients.
Abstract: CPAP is a simple and effective ventilatory treatment for acute respiratory failure related to specific conditions. CPAP (10 cm H2O) should be considered as the first-line ventilator treatment for achieving prompt physiologic improvement and lower rates of endotracheal intubation in severe cardiogenic pulmonary edema. CPAP is effective for managing postoperative hypoxemia, enabling improved outcomes in selected patients, provided it is applied for a sufficient period of time. CPAP is also useful during fiberoptic bronchoscopy in hypoxemic patients to prevent subsequent acute respiratory failure. Although application of non-invasive CPAP cannot be generally recommended in the early stage of hypoxemic acute respiratory failure related to ALI/ARDS or pneumonia, CPAP may be beneficial in high-risk, immunocompromised patients. Surprisingly, no study has yet evaluated the effectiveness of early use of CPAP alone in improving outcome in patients with acute exacerbation of COPD. In contrast, use of PEEP/CPAP is often detrimental and is not advisable in other conditions, such as in patients undergoing mechanical ventilation for acute severe asthma.
01 Jan 2006