M
Massimo Santoro
Researcher at University of Turin
Publications - 185
Citations - 15848
Massimo Santoro is an academic researcher from University of Turin. The author has contributed to research in topics: Thyroid carcinoma & Thyroid. The author has an hindex of 66, co-authored 173 publications receiving 14778 citations. Previous affiliations of Massimo Santoro include Flanders Institute for Biotechnology & University of Eastern Piedmont.
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Journal Article
Molecular characterization of RET/PTC3; A novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma
Massimo Santoro,Nina A. Dathan,Maria Teresa Berlingieri,Italia Bongarzone,Christian Paulin,M. Grieco,Marco A. Pierotti,Giancarlo Vecchio,Alfredo Fusco +8 more
TL;DR: The identification and cloning of a novel rearranged version of the RET oncogene in a human thyroid papillary carcinoma and evidence indicating that the rearrangement leading to the generation of RET/PTC3 occurred in vivo in the original tumor DNA is provided.
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Mutation of the PIK3CA gene in anaplastic thyroid cancer.
Ginesa Garcia-Rostan,Angela M. Costa,Isabel Pereira-Castro,Giuliana Salvatore,Radhames Hernandez,Mario J.A. Hermsem,Agustin Herrero,Alfredo Fusco,José Cameselle-Teijeiro,Massimo Santoro +9 more
TL;DR: Findings indicate that mutant PIK3CA is likely to function as an oncogene among ATC and less frequently well-differentiated thyroid carcinomas, and argue for a role of Pik3CA targeting in the treatment of ATC patients.
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The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
Rosa Marina Melillo,Maria Domenica Castellone,Valentina Guarino,Valentina De Falco,Anna Maria Cirafici,Giuliana Salvatore,Fiorina Caiazzo,Fulvio Basolo,Riccardo Giannini,Mogens Kruhøffer,Torben F. Ørntoft,Alfredo Fusco,Massimo Santoro +12 more
TL;DR: Gene expression profiling revealed that the 3 oncogenes activate a common transcriptional program in thyroid cells that includes upregulation of the CxCL1 and CXCL10 chemokines, which in turn stimulate proliferation and invasion.
Journal ArticleDOI
RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.
Giovanni Gaudino,Antonia Follenzi,Luigi Naldini,Chiara Collesi,Massimo Santoro,Kathleen A. Gallo,Paul J. Godowski,Paolo M. Comoglio +7 more
TL;DR: The data show that p185RON is a tyrosine kinase activated by MSP and that it is member of a family of growth factor receptors with distinct specificities for structurally related ligands.
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The RET receptor: function in development and dysfunction in congenital malformation
TL;DR: These findings, which provide new clues to the molecular mechanisms underlying RET signalling dysfunction in Hirschsprung disease, are summarized in this review.