M
Massimo Santoro
Researcher at University of Turin
Publications - 185
Citations - 15848
Massimo Santoro is an academic researcher from University of Turin. The author has contributed to research in topics: Thyroid carcinoma & Thyroid. The author has an hindex of 66, co-authored 173 publications receiving 14778 citations. Previous affiliations of Massimo Santoro include Flanders Institute for Biotechnology & University of Eastern Piedmont.
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Journal ArticleDOI
The RFG oligomerization domain mediates kinase activation and re-localization of the RET/PTC3 oncoprotein to the plasma membrane.
Carmen Monaco,Roberta Visconti,Maria Vittoria Barone,Giovanna Maria Pierantoni,Maria Terasa Berlingieri,Claudia De Lorenzo,A. Mineo,Giancarlo Vecchio,Alfredo Fusco,Massimo Santoro +9 more
TL;DR: It is proposed that fusion to the RFG coiled-coil domain provides RET kinase with a scaffold that mediates oligomerization and re-localization of the RET/PTC3 protein, a process that may be crucial for the signalling of this specific RET/ PTC variant.
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RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.
Valentina De Falco,Maria Domenica Castellone,Gabriella De Vita,Anna Maria Cirafici,Jerome M. Hershman,Carmen Guerrero,Alfredo Fusco,R. M. Melillo,Massimo Santoro +8 more
TL;DR: Ret/papillary thyroid carcinoma oncoproteins result from the in-frame fusion of the RET receptor tyrosine kinase with protein dimerization motifs encoded by heterologous genes and Rap1 is a downstream effector of RET/PTC and may contribute to the transformed phenotype of RET-expressing thyrocytes.
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Overexpression of the cytokine osteopontin identifies aggressive laryngeal squamous cell carcinomas and enhances carcinoma cell proliferation and invasiveness.
Angela Celetti,Domenico Testa,Stefania Staibano,Francesco Merolla,Valentina Guarino,Maria Domenica Castellone,R Iovine,Gelsomina Mansueto,Pasquale Somma,Gaetano De Rosa,Vieri Galli,Rosa Marina Melillo,Massimo Santoro +12 more
TL;DR: Osteopontin is identified as a marker and a potential therapeutic target in cases of aggressive laryngeal squamous cell carcinomas and its expression levels were significantly correlated with tumor stage and grade and with the presence of lymph node and distant metastases.
Journal ArticleDOI
Cilia Control Vascular Mural Cell Recruitment in Vertebrates
TL;DR: It is found that vMCs are recruited by arterial-fated vessels and that the process is flow dependent, and it is demonstrated that hemodynamic-dependent Notch activation and the ensuing arterial genetic program is driven by endothelial primary cilia.
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Increase in AP-1 activity is a general event in thyroid cell transformation in vitro and in vivo
Sabrina Battista,Filomena de Nigris,Monica Fedele,Gennaro Chiappetta,Stefania Scala,Daniela Vallone,Giovanna Maria Pierantoni,Tiziana Megar,Massimo Santoro,Giuseppe Viglietto,Pasquale Verde,Alfredo Fusco +11 more
TL;DR: In vivo and in vitro thyroid cell transformation is associated with important compositional changes in the AP-1 complex and an increased transcriptional activity, which is represented by the dramatic junB and fra-1 gene induction.