M
Massimo Santoro
Researcher at University of Turin
Publications - 185
Citations - 15848
Massimo Santoro is an academic researcher from University of Turin. The author has contributed to research in topics: Thyroid carcinoma & Thyroid. The author has an hindex of 66, co-authored 173 publications receiving 14778 citations. Previous affiliations of Massimo Santoro include Flanders Institute for Biotechnology & University of Eastern Piedmont.
Papers
More filters
Journal ArticleDOI
Blood flow controls bone vascular function and osteogenesis.
Saravana K. Ramasamy,Saravana K. Ramasamy,Anjali P. Kusumbe,Anjali P. Kusumbe,Maria Schiller,Dagmar Zeuschner,M. Gabriele Bixel,Carlo Milia,Jaba Gamrekelashvili,Anne Limbourg,Alexander Medvinsky,Massimo Santoro,Massimo Santoro,Florian P. Limbourg,Ralf H. Adams +14 more
TL;DR: It is proposed that blood flow and endothelial Notch signalling are key factors controlling ageing processes in the skeletal system.
Journal ArticleDOI
Disease associated mutations at valine 804 in the RET receptor tyrosine kinase confer resistance to selective kinase inhibitors.
Francesca Carlomagno,Teresa Guida,Suresh Anaganti,Giancarlo Vecchio,Alfredo Fusco,Anderson J. Ryan,Marc Billaud,Massimo Santoro +7 more
TL;DR: It is shown that most oncogenic MEN2-associated RET kinase mutants are highly susceptible to PP1, PP2 and ZD6474 inhibition, and valine 804 of RET is identified as a structural determinant mediating resistance to pyrazolopyrimidines and 4-anilinoquinazolines.
Journal Article
Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice.
Massimo Santoro,Gennaro Chiappetta,Aniello Cerrato,Domenico Salvatore,Li Zhang,G. Manzo,Alessandro Picone,Giuseppe Portella,Giovanni Santelli,Giancarlo Vecchio,Alfredo Fusco +10 more
TL;DR: The generation of transgenic mice lines expressing the RET/PTC1 oncogene under the control of the thyroid-specific rat thyroglobulin promoter developed thyroid tumors displaying the histological aspect of papillary carcinomas.
Journal ArticleDOI
The MSP Receptor Regulates α6β4 and α3β1 Integrins via 14-3-3 Proteins in Keratinocyte Migration
TL;DR: A mechanism based on MSP-Ron-dependent phosphorylation and 14-3-3 association is proposed, whereby the function of α6β4 switches from a mechanical adhesive device into a signaling component, and might be critically involved in human epidermal wound healing.
Journal Article
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis.
Sabrina Battista,Vincenzo Fidanza,Monica Fedele,Andres J. Klein-Szanto,Eric Outwater,Han Brunner,Massimo Santoro,Carlo M. Croce,Alfredo Fusco +8 more
TL;DR: Transgenic mice carrying a HMGI-C construct, containing only the three AT-hook domains, showed a giant phenotype, together with a predominantly abdominal/pelvic lipomatosis, suggesting a pivotal role of the HM GI-C truncation in the generation of human lipomas.