M
Massimo Tommasino
Researcher at International Agency for Research on Cancer
Publications - 334
Citations - 14170
Massimo Tommasino is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Cancer & HPV infection. The author has an hindex of 62, co-authored 312 publications receiving 12239 citations. Previous affiliations of Massimo Tommasino include German Cancer Research Center & World Health Organization.
Papers
More filters
Journal ArticleDOI
Determination of the binding affinity of different human papillomavirus E7 proteins for the tumour suppressor pRb by a plate-binding assay.
TL;DR: The data indicate that the high affinity pRb-binding domain of E7, LXCXE, is essential for the association between the viral and cellular proteins, however, other E7 domain(s), which appear not to be present in all E7s, contribute to stabilize the E7-pRb association.
Journal ArticleDOI
Human papillomavirus type 38 E6 and E7 act as tumour promoters during chemically induced skin carcinogenesis.
Daniele Viarisio,Karin Müller Decker,Birgit Aengeneyndt,Christa Flechtenmacher,Lutz Gissmann,Lutz Gissmann,Massimo Tommasino +6 more
TL;DR: It is shown that beta HPV38 E6 and E7 oncoproteins act as promoter and progression factors in multi-stage skin carcinogenesis, strongly cooperating with the initiator and DNA damage agent 7,12-dimethylbenz[a]anthracene.
Journal ArticleDOI
Prevalence of human papillomavirus types in cervical lesions from women in rural Western India
Kedar Deodhar,Tarik Gheit,Salvatore Vaccarella,Christine Carreira Romao,Vanessa Tenet,Bhagwan M. Nene,Kasturi Jayant,Rohini Kelkar,Sylla G. Malvi,Bakary S. Sylla,Silvia Franceschi,Jose Jeronimo,Surendra S Shastri,Rengaswamy Sankaranarayanan,Massimo Tommasino +14 more
TL;DR: The HPV genotyping data showing a high HPV 16 and 18 prevalence in cancer specimens indicate that prophylactic HPV 16/18 vaccination would have a significant impact on the prevention of cervical cancer in India.
Journal ArticleDOI
Novel ß-HPV49 Transgenic Mouse Model of Upper Digestive Tract Cancer.
Daniele Viarisio,Karin Müller-Decker,Paola Zanna,Ulrich Kloz,Birgit Aengeneyndt,Rosita Accardi,Christa Flechtenmacher,Lutz Gissmann,Massimo Tommasino +8 more
TL;DR: This study studied the effects of ß-3 type HPV49 in a novel transgenic mouse model, using a cytokeratin K14 promoter to drive expression of the E6 and E7 genes from this virus in the basal skin epidermis and the mucosal epithelia of the digestive tract.
Journal ArticleDOI
Comprehensive Analysis of HPV Expression in Laryngeal Squamous Cell Carcinoma
Tarik Gheit,Behnoush Abedi-Ardekani,Christine Carreira,Carlos G. Missad,Massimo Tommasino,Mariela C. Torrente +5 more
TL;DR: HPV appears to play an active role in a small subset of laryngeal squamous cell carcinoma, and p16INK4a can be used as a surrogate marker of transcriptionally active HPV infection.