Massimo Tommasino

TL;DR: The role of the soft tissue tract between the primary tumor and the neck lymph nodes, the “T‐N tract,” in patients with tongue squamous cell carcinoma at an advanced stage is investigated.

TL;DR: A large number of women infected with HPV 16 with normal cytology, without previous treatment for cervical lesions, and with a valid second follow-up visit 4 to 16 months later were selected from patients participating in routine cervical cancer screening in the Reims HPV Primary Screening Cohort Study.

TL;DR: This analysis may inform choices for HPV genotyping methods in epidemiological studies, when the relative merits and dangers of sensitivity versus specificity for individual types should be considered, as well as the potential to unmask nonvaccine types following HPV vaccination.

TL;DR: Evidence is presented that the NF-κB signaling activator, tumor necrosis factor (TNF)-α, induces the accumulation of HBx in cells by increasing protein stability due to reduced proteasomal degradation, and it is shown that the increased level of HBX in cells cooperates with TNF-α toward activation of NF-σB and expression of NF -κB-regulated genes, indicating a positive feedback loop between HBx and NF-γB signaling.

TL;DR: It is demonstrated for the first time that the OCTN2 transporter is generally down‐regulated in virus and nonvirus‐mediated epithelial cancers, probably via methylation of its promoter region.