M
Massimo Tommasino
Researcher at International Agency for Research on Cancer
Publications - 334
Citations - 14170
Massimo Tommasino is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Cancer & HPV infection. The author has an hindex of 62, co-authored 312 publications receiving 12239 citations. Previous affiliations of Massimo Tommasino include German Cancer Research Center & World Health Organization.
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Journal ArticleDOI
Human papillomavirus type 16 E6 inhibits p21WAF1 transcription independently of p53 by inactivating p150Sal2
Peggy Parroche,Majid Touka,Mariam Mansour,Véronique Bouvard,Amélie Thépot,Rosita Accardi,Christine Carreira,Guillaume Roblot,Bakary S. Sylla,Uzma Hasan,Massimo Tommasino +10 more
TL;DR: A novel mechanism by which HPV16 E6 induces cell cycle deregulation with a p53-independent pathway is described, which targets p150(Sal2), a positive transcription regulator of p21(WAF1) gene, preventing G1/S arrest and allowing cellular proliferation and efficient viral DNA replication.
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The mycotoxin aflatoxin B1 stimulates Epstein–Barr virus-induced B-cell transformation in in vitro and in vivo experimental models
Rosita Accardi,Henri Gruffat,Cecilia Sirand,Floriane Fusil,Tarik Gheit,Hector Hernandez-Vargas,Florence Le Calvez-Kelm,Alexandra Traverse-Glehen,François-Loïc Cosset,Evelyne Manet,Christopher P. Wild,Massimo Tommasino +11 more
TL;DR: It is shown that exposure to AFB1 in in vitro and in vivo models induces activation of the EBV lytic cycle and increases EBV load, two events that are associated with an increased risk of eBL in vivo.
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Differential presence of Papillomavirus variants in cervical cancer: An analysis for HPV33, HPV45 and HPV58
J.M. Godínez,Daniëlle A.M. Heideman,Tarik Gheit,Laia Alemany,Peter J.F. Snijders,Massimo Tommasino,Chris J.L.M. Meijer,S de Sanjosé,Franz X. Bosch,Ignacio G. Bravo +9 more
TL;DR: This is the first study trying to discern the phylogenetic connection between variants of the oncogenic HPV33, 45 and 58, and squamous cell carcinoma of the cervix.
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Human papillomavirus genotypes in cervical and other HPV-related anogenital cancer in Rwanda, according to HIV status.
Tharcisse Mpunga,Marie Chantal Umulisa,Vanessa Tenet,Belson Rugwizangoga,Danny A. Milner,Cyprien Munyanshongore,Daniëlle A M Heideman,Maaike C G Bleeker,Massimo Tommasino,Silvia Franceschi,Iacopo Baussano,Tarik Gheit,Felix Sayinzoga,Gary M. Clifford +13 more
TL;DR: Impact of HIV on the distribution of causal HPV types was relatively minor, confirming type‐specific relevance of HPV vaccines, irrespective of HIV status, and the preventive potential of the ongoing national HPV vaccination program in Rwanda, and in sub‐Saharan Africa as a whole.
Journal ArticleDOI
Assessment of Transformed Properties In Vitro and of Tumorigenicity In Vivo in Primary Keratinocytes Cultured for Epidermal Sheet Transplantation
Amélie Thépot,A. Desanlis,E. Venet,L. Thivillier,Virginie Justin,Anne-Pierre Morel,F. DeFraipont,M. Till,Vladimir Krutovskikh,Massimo Tommasino,Odile Damour,Pierre Hainaut +11 more
TL;DR: The current protocol for keratinocyte transplant therapy does not result in an increased risk of tumorigenicity of transplanted cells, and none of the cultures displayed characteristics of cell transformations, implying that the culture protocol does not generate artefacts leading to the selection of transformed cells.