M
Massimo Tommasino
Researcher at International Agency for Research on Cancer
Publications - 334
Citations - 14170
Massimo Tommasino is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Cancer & HPV infection. The author has an hindex of 62, co-authored 312 publications receiving 12239 citations. Previous affiliations of Massimo Tommasino include German Cancer Research Center & World Health Organization.
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Journal Article
Functional studies of E7 proteins from different HPV types.
TL;DR: Although HPV1 E7 showed the same affinity in vitro and in vivo as the high risk HPV E7s, it did not have the ability to activate the E2F-1 transcription factor inhibited by Rb1, nor did it have any transforming activity when coexpressed with activated ras in primary rodent cells.
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The N-terminal region of the human papillomavirus L2 protein contains overlapping binding sites for neutralizing, cross-neutralizing and non-neutralizing antibodies.
Ivonne Rubio,Hanna Seitz,Elena Canali,Peter Sehr,Angelo Bolchi,Massimo Tommasino,Simone Ottonello,Martin Müller +7 more
TL;DR: The data indicate that restriction of neutralization to HPV16 is due to sequence (or structural) differences laying outside of the epitope, and may pave the way to novel vaccination approaches specifically evoking cross-neutralizing antibody responses.
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TP53 mutations in squamous-cell carcinomas of the conjunctiva: evidence for UV-induced mutagenesis.
Charles Ateenyi-Agaba,Min Dai,Florence Le Calvez,Edward Katongole-Mbidde,Anouk Smet,Massimo Tommasino,Silvia Franceschi,Pierre Hainaut,Elisabete Weiderpass +8 more
TL;DR: The results confirm at the molecular level the causal role of solar UV rays in the aetiology of squamous cell carcinoma of the conjunctiva and suggest that infection with epidermodysplasia verruciformis types of human papillomavirus may act as a cofactor to increase the sensitivity of conjunctivas cells to UV-induced mutagenesis.
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The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells.
Angelo Paradiso,Rosa Angela Cardone,Antonia Bellizzi,Anna Bagorda,Lorenzo Guerra,Massimo Tommasino,Valeria Casavola,Stephan J. Reshkin +7 more
TL;DR: The findings suggest that the reported antagonistic roles of RhoA and Rac1 in cell motility/invasion and cytoskeletal organization may be due, in part, to their concerted action on NHE1 activity as a convergence point.
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Beta HPV38 oncoproteins act with a hit-and-run mechanism in ultraviolet radiation-induced skin carcinogenesis in mice
Daniele Viarisio,Karin Müller-Decker,Rosita Accardi,Alexis Robitaille,Matthias Dürst,Katrin Beer,Lars Jansen,Christa Flechtenmacher,Matthias Bozza,Richard Harbottle,Catherine Voegele,Maude Ardin,Jiri Zavadil,Sandra Caldeira,Lutz Gissmann,Massimo Tommasino +15 more
TL;DR: Findings support the concept that beta HPV types act only at an initial stage of carcinogenesis, by potentiating the deleterious effects of UV radiation.