Massoud Mirshahi

TL;DR: The results illustrate the perfusion-independent role of the endothelium by showing a direct endothelial to cancer cell mitochondrial exchange associated to phenotypic modulation, which supports another role in the constitution of the metastatic niche.

TL;DR: In vivo induction of endothelial apoptosis leads to both vessel thrombosis and endothelial denudation, which may be a critical step in the transition from a stable endothelialized plaque to plaque erosion and thromBosis.

TL;DR: Albumin nanoparticles were proved to be effective and safe carriers for delivering anticytomegaloviral compounds in the vitreous and improved the antiviral activity of both ganciclovir and the phosphodiester oligonucleotide analog to formivirsen.

TL;DR: The vision was not affected by autoimmune phenomena or alterations in the behavior of ophthalmic cells due to the intravitreal injection of ganciclovir-loaded bovine serum albumin nanoparticles, and the histological evaluation of the retina, mainly the photoreceptor layer, and adjacent tissues revealed the absence of inflammatory reactions or alteration in the tissue architecture.

TL;DR: These studies suggest that the transcriptional regulation of the ENaC gene by the MCR-mediated signalling is not restricted to epithelial cells and requires cytoskeleton integrity in ECV cells in situ, tubulin may form a new and novel mediator in cell regulation, and the vascular tone may actually be regulated via transactivation of the ion gated sodium channel in the endothelial cell of the blood vessels under direct, receptor-mediated action of aldosterone.