Matilde Todaro

TL;DR: The latest findings regarding the contribution of IFNs in colorectal cancer and melanoma are described by researching their dual role as either tumor promoter or suppressor, in diverse tumor types, and microenvironmental context.

TL;DR: A subset of human Vγ9Vδ2 lymphocytes, which, upon interaction with IL-21-producing CD4 TFH cells and B cells in secondary lymphoid organs, is implicated in the production of high affinity antibodies against microbial pathogens.

TL;DR: Current cancer treatments, based on the assumption that tumour cell population responds homogeneously, have been developed to eradicate proliferating cells, but the new model of tumorigenesis entails significant therapeutic implications, in fact if a small fraction of CICs survives conventional therapy it may lead to recurrence after month or years of apparent remission.

TL;DR: It is shown that human breast cancer cells express high levels of PED and that AKT activity regulates PED protein levels, and AKT-dependent increase of P ED expression levels represents a key molecular mechanism for chemoresistance in breast cancer.

TL;DR: It is shown that tumorigenic colon cancer cells can be found in a rapidly proliferating state in vitro and in vivo, both in human tumors and mouse xenografts and indicates Plk1 inhibitors as potentially useful in the treatment of colorectal cancer.