M
Matilde Todaro
Researcher at University of Palermo
Publications - 163
Citations - 19136
Matilde Todaro is an academic researcher from University of Palermo. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 55, co-authored 154 publications receiving 17289 citations. Previous affiliations of Matilde Todaro include University of Rome Tor Vergata.
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Journal ArticleDOI
Human NK Cells Selective Targeting of Colon Cancer–Initiating Cells: A Role for Natural Cytotoxicity Receptors and MHC Class I Molecules
Rossana Tallerico,Matilde Todaro,Simone Di Franco,Cristina Maccalli,Cinzia Garofalo,Rosa Sottile,Camillo Palmieri,Luca Tirinato,Pradeepa N. Pangigadde,Rosanna La Rocca,Ofer Mandelboim,Giorgio Stassi,Enzo Di Fabrizio,Giorgio Parmiani,Alessandro Moretta,Francesco Dieli,Klas Kärre,Ennio Carbone +17 more
TL;DR: The data demonstrate that freshly purified allogeneic NK cells can recognize and kill colorectal carcinoma–derived CICs whereas the non-CIC counterpart of the tumors (differentiated tumor cells), either autologous or allogenicic, is less susceptible to NK cells.
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Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging.
Luca Tirinato,Carlo Liberale,Simone Di Franco,Simone Di Franco,Patrizio Candeloro,Antonina Benfante,Rosanna La Rocca,Lisette Potze,Roberto Marotta,Roberta Ruffilli,Vijayakumar P. Rajamanickam,Mario Malerba,Francesco De Angelis,Andrea Falqui,Ennio Carbone,Matilde Todaro,Jan Paul Medema,Giorgio Stassi,Enzo Di Fabrizio +18 more
TL;DR: It is shown that high levels of lipid droplets (LDs) are a distinctive mark of CSCs in colorectal (CR) cancer, and this increased lipid content was clearly revealed by label‐free Raman spectroscopy and it directly correlates with well‐accepted CR‐CSC markers as CD133 and Wnt pathway activity.
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GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion
Maria Rita Rippo,Florence Malisan,Luigi Ravagnan,Barbara Tomassini,Ivano Condò,P. Costantini,Santos A. Susin,Alessandra Rufini,Matilde Todaro,Guido Kroemer,Roberto Testi +10 more
TL;DR: It is shown that mitochondria are a key destination for apoptogenic GD3 ganglioside along the lipid pathway to programmed cell death and indicate that relevant GD3 targets are under bcl‐2 control.
Journal ArticleDOI
Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function
Gianluigi Condorelli,Roberta Roncarati,John Ross,Angela Pisani,Giorgio Stassi,Matilde Todaro,Stephen Trocha,Alessandra Drusco,Yusu Gu,Matteo Antonio Russo,Giacomo Frati,Steven P. Jones,David J. Lefer,Claudio Napoli,Carlo M. Croce +14 more
TL;DR: An unexpected property of the proapoptotic gene caspase3 on cardiac contractility is documented, despite inducing ultrastructural damage, that does not trigger a full apoptotic response in the cardiomyocyte.