Matilde Todaro

TL;DR: Basic research has indicated apoptosis as the pivotal molecular mechanism leading to autoimmunity and recently cytokines have been invoked in the regulation of the apoptosis-related factors and death receptors in autoimmune target destruction.

TL;DR: Stem cell factor treatment can prevent the occurrence of chemotherapy-induced anemia and thrombocytopenia in mice, indicating a potential use of this cytokine in the supportive therapy of cancer patients.

TL;DR: It is shown that miR-205-5p regulates tumorigenic properties of breast cancer cells, as well as epithelial to mesenchymal transition, and can be obtained with the use of specific locked nucleic acids oligonucleotides in vivo suggesting a future potential use of this approach in therapy.

TL;DR: Increasing understanding of the cellular and molecular mechanisms that regulate CSC quiescence and cell cycle regulation, self-renewal, chemotaxis and resistance to cytotoxic agents, is expected to eventually result in tailor-made therapies with a significant impact on the morbidity and overall survival of colorectal cancer patients.

TL;DR: New insights into thyroid SCs are critically discussed as a potential source of cancer formation in light of the available information on the oncogenic role of genetic modifications that occur during thyroid cancer development.