M
Matilde Todaro
Researcher at University of Palermo
Publications - 163
Citations - 19136
Matilde Todaro is an academic researcher from University of Palermo. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 55, co-authored 154 publications receiving 17289 citations. Previous affiliations of Matilde Todaro include University of Rome Tor Vergata.
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Journal ArticleDOI
Capturing Colorectal Cancer Inter-Tumor Heterogeneity in Patient-Derived Xenograft (PDX) Models
Pramudita R. Prasetyanti,Sander R. van Hooff,Tessa van Herwaarden,Nathalie R. de Vries,Kieshen Kalloe,Hans M. Rodermond,Ronald van Leersum,Joan H. de Jong,Marek Franitza,Peter Nürnberg,Matilde Todaro,Giorgio Stassi,Jan Paul Medema +12 more
TL;DR: It was shown that tumor cell proliferation was associated with successful PDX establishment and able to distinguish patient with poor clinical outcomes within CMS2 group, indicating the need for further optimization to develop an effective personalized therapeutic approach to CRC.
Journal ArticleDOI
Accumulation of circulating CCR7+ natural killer cells marks melanoma evolution and reveals a CCL19-dependent metastatic pathway
Costanza Maria Cristiani,Alice Turdo,Valeria Ventura,Tiziana Apuzzo,Mariaelena Capone,Gabriele Madonna,Domenico Mallardo,Cinzia Garofalo,Emilia Dora Giovannone,Antonio M. Grimaldi,Rossana Tallerico,Emanuela Marcenaro,Silvia Pesce,Genny Del Zotto,Valter Agosti,Francesco Costanzo,Elio Gulletta,Aroldo Rizzo,Alessandro Moretta,Klas Kärre,Paolo A. Ascierto,Matilde Todaro,Ennio Carbone +22 more
TL;DR: The data identify biomarkers that may mark a CCR7-driven metastatic melanoma pathway and suggest that melanoma progression leads to changes in peripheral blood NK and T-cell subsets.
Journal ArticleDOI
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Simone Di Franco,Paola Bianca,Davide Stefano Sardina,Alice Turdo,Miriam Gaggianesi,Veronica Veschi,Annalisa Nicotra,Laura Rosa Mangiapane,Melania Lo Iacono,Irene Pillitteri,Sander R. van Hooff,Federica Martorana,Gianmarco Motta,Eliana Gulotta,Vincenzo Luca Lentini,Emanuele Martorana,Micol E. Fiori,Salvatore Vieni,Maria Rita Bongiorno,Giorgio Giannone,Dario Giuffrida,Lorenzo Memeo,Lorenzo Colarossi,Marzia Mare,Paolo Vigneri,Matilde Todaro,Ruggero De Maria,Jan Paul Medema,Giorgio Stassi +28 more
TL;DR: In this article, the authors show that visceral adipose derived factors promote vasculogenesis and metastatic dissemination by activation of STAT3, which inhibits miR-200a and enhances ZEB2 expression, effectively reprogramming colorectal cancer cells into a highly metastatic phenotype.
Journal ArticleDOI
CD133 as a target for colon cancer
Veronica Catalano,Simone Di Franco,Flora Iovino,Francesco Dieli,Giorgio Stassi,Matilde Todaro +5 more
TL;DR: The focus of the discussion is on the need for additional markers to better identify the cell population able to recapitulate the parental tumor in immunocompromised mice.
Journal ArticleDOI
p63 isoforms regulate metabolism of cancer stem cells
Simona D'Aguanno,Daniela Barcaroli,Claudia Rossi,Mirco Zucchelli,Domenico Ciavardelli,Domenico Ciavardelli,Claudio Cortese,Antonella De Cola,Silvia Volpe,Daniela D'Agostino,Matilde Todaro,Giorgio Stassi,Carmine Di Ilio,Andrea Urbani,Vincenzo De Laurenzi +14 more
TL;DR: The results indicate that p63 is implicated in a wide range of biological processes, including metabolism, and shows that TAp63 overexpressing cells are more glycolytic-active than ΔNp63 cells, indicating that the two isoforms may regulate the key steps of glyCOlysis in an opposite manner.