https://cancerbiologyprogram.med.wayne.edu/pdfs/hallmarks_cancer_article.pdf

Hallmarks of cancer: the next generation.

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression. This switch in cell differentiation and behaviour is mediated by key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix-loop-helix transcription factors, the functions of which are finely regulated at the transcriptional, translational and post-translational levels. The reprogramming of gene expression during EMT, as well as non-transcriptional changes, are initiated and controlled by signalling pathways that respond to extracellular cues. Among these, transforming growth factor-β (TGFβ) family signalling has a predominant role; however, the convergence of signalling pathways is essential for EMT.

Molecular mechanisms of epithelial–mesenchymal transition

https://web.stanford.edu/group/nusselab/cgi-bin/wnt/sites/default/files/reviews/Cell%202012%20Clevers.pdf

Wnt/β-catenin signaling and disease.

Oxidative Stress, Inflammation, and Cancer: How Are They Linked?

The invention concerns a method for diagnosing a cancer type, whereby the expression of anti-apoptotic cytokines is determined in the tumour cells. The differential diagnosis of the present invention is used to classify tumour disorders and to recommend the required treatment and to monitor the progress and response to the treatment.

Differential il-4 and/or il-10 cytokine expression in human cancer

Colorectal cancer is the fourth most common cause of cancer-related death. Although many advances in the treatment of this disease have been made, a large number of patients develop metastasis and resistance to current therapies. The current evidence indicates that cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT) have crucial roles in colorectal carcinogenesis and metastasis. It is also very important to understand the mechanisms that allow the survival of CSCs, such as metabolic reprogramming, which permits them to obtain specific properties or the activation of alternative signaling pathways in response to first-line therapies. In this review, we discuss the failure of conventional therapies for colorectal cancer and provide a brief analysis of new therapeutic strategies for targeting non-responsive CSC. We highlight the use of combination therapies, such as horizontal or vertical targeting, as the most efficient strategy for eradicating these subpopulations of cancer cells.

Innovative Therapeutic Strategies Targeting Colorectal Cancer Stem Cells

Sensibilisierung von Zellen für die Apoptose durch selektive Blockade von Zytokinen

L'invention concerne un procede de diagnostic du type de cancer consistant a determiner l'expression de cytokines anti-apoptotiques dans les cellules cancereuses. Le diagnostic differentiel de la presente invention permet de classifier les troubles tumoraux, de recommander le traitement adequat et de suivre le progres dudit traitement et la reponse au traitement.

Matilde Todaro

Papers

Differential il-4 and/or il-10 cytokine expression in human cancer

Innovative Therapeutic Strategies Targeting Colorectal Cancer Stem Cells

Sensibilisierung von Zellen für die Apoptose durch selektive Blockade von Zytokinen

Expression différentielle de la cytokine dans les cancers chez l'homme

Erfassungszellen zur Apoptose durch selektiv blockierende Cytokine