M
Matthew L. Thomas
Researcher at Washington University in St. Louis
Publications - 62
Citations - 8676
Matthew L. Thomas is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Protein tyrosine phosphatase & Receptor tyrosine kinase. The author has an hindex of 38, co-authored 62 publications receiving 8510 citations. Previous affiliations of Matthew L. Thomas include Howard Hughes Medical Institute & University of Tokyo.
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Journal ArticleDOI
CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development
TL;DR: Evidence from genetic experiments indicates that CD45 plays a pivotal role in antigen-stimulated proliferation of T lymphocytes and in thymic development, and analysis of CD45 isoform expression has revealed a hitherto unrecognized plasticity in isoform usage by T cells and other leukocytes, adding to the regulatory complexity ofisoform expression.
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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.
Leonard D. Shultz,Peter A. Schweitzer,Thiruchandurai V. Rajan,Taolin Yi,James N. Ihle,R. James Matthews,Matthew L. Thomas,David R. Beier +7 more
TL;DR: DNA sequence analyses of cDNA and genomic clones revealed that both the me and mev mutations are point mutations that result in aberrant splicing of the Hcph transcript, thus facilitating determination of the precise role of this signaling molecule in hematopoiesis.
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The leukocyte common antigen family.
TL;DR: The leukocyte-common antigen (L-CA) family is a group of high molecular weight glycoproteins uniquely expressed on the surface of all leukocytes and their hemopoietic progenitors and is a major cell surface component of lymphocytes and carries much of the carbohydrate of these cells.
Journal ArticleDOI
A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP
Gina M. Doody,Louis B. Justement,C. C. Delibrias,R. J. Matthews,Jiejian Lin,Matthew L. Thomas,Douglas T. Fearon +6 more
TL;DR: CD22 is a molecular switch for SHP that may bias mIg signaling to anatomic sites rich in T cells and be sequestered away from mIG through interactions with counterreceptors on T cells.
Journal ArticleDOI
Normal B lymphocyte development but impaired T cell maturation in CD45-Exon6 protein tyrosine phosphatase-deficient mice
Kenji Kishihara,Kenji Kishihara,Josef M. Penninger,Josef M. Penninger,Valerie A. Wallace,Valerie A. Wallace,Thomas M. Kündig,Kazuhiro Kawal,Andrew Wakeham,Andrew Wakeham,Emma Timms,Emma Timms,Klaus Pfeffer,Klaus Pfeffer,Pamela S. Ohashi,Matthew L. Thomas,Caren Furlonger,Christopher J. Paige,Tak W. Mak,Tak W. Mak +19 more
TL;DR: The data imply that CD45 is differentially required for the development and function of B and T lymphocytes, as shown in mice generated with a mutation in the variable CD45 exon 6.